Mapping the journey from totipotency to lineage specification in the mouse embryo.
Leung, Chuen Yan
Current Opinion in Genetics and Development
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Leung, C. Y., & Zernicka-Goetz, M. (2015). Mapping the journey from totipotency to lineage specification in the mouse embryo.. Current Opinion in Genetics and Development, 34 71-76. https://doi.org/10.1016/j.gde.2015.08.002
Understanding the past is to understand the present. Mammalian life, with all its complexity comes from a humble beginning of a single fertilized egg cell. Achieving this requires an enormous diversification of cellular function, the majority of which is generated through a series of cellular decisions during embryogenesis. The first decisions are made as the embryo prepares for implantation, a process that will require specialization of extra-embryonic lineages while preserving an embryonic one. In this mini-review, we will focus on the mouse as a mammalian model and discuss recent advances in the decision making process of the early embryo.
Animals, Cell Differentiation, Cell Lineage, Embryo Implantation, Embryo, Mammalian, Embryonic Development, Mice, Signal Transduction, Totipotent Stem Cells
We are grateful to the Wellcome Trust for supporting the research in our group
External DOI: https://doi.org/10.1016/j.gde.2015.08.002
This record's URL: https://www.repository.cam.ac.uk/handle/1810/253277
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nc-nd/4.0/
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