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dc.contributor.authorBell, Nicholasen
dc.contributor.authorMuthukumar, Murugappanen
dc.contributor.authorKeyser, Ulrichen
dc.date.accessioned2016-01-15T15:24:30Z
dc.date.available2016-01-15T15:24:30Z
dc.date.issued2016-02-01en
dc.identifier.citationBell et al. Physical Review E (2016) Vol. 93, Article 022401. doi: 10.1103/PhysRevE.93.022401en
dc.identifier.issn2470-0045
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253306
dc.description.abstractSolid-state nanopores are single molecule sensors that measure changes in ionic current as charged polymers such as DNA pass through. Here, we present comprehensive experiments on the length, voltage and salt dependence of the frequency of double-stranded DNA translocations through conical quartz nanopores with mean opening diameter 15 nm. We observe an entropic barrier limited, length dependent translocation frequency at 4M LiCl salt concentration and a drift-dominated, length independent translocation frequency at 1M KCl salt concentration. These observations are described by a unifying convection-diffusion equation which includes the contribution of an entropic barrier for polymer entry.
dc.languageEnglishen
dc.language.isoenen
dc.publisherAmerican Physical Society
dc.titleTranslocation frequency of double-stranded DNA through a solid-state nanoporeen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from the American Physical Society via http://dx.doi.org/10.1103/PhysRevE.93.022401en
prism.number022401en
prism.publicationDate2016en
prism.publicationNamePhysical Review Een
prism.volume93en
dc.rioxxterms.funderEPSRC
dc.rioxxterms.funderERC
dc.rioxxterms.funderNIHR
rioxxterms.versionofrecord10.1103/PhysRevE.93.022401en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-02-01en
dc.contributor.orcidKeyser, Ulrich [0000-0003-3188-5414]
dc.identifier.eissn2470-0053
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEuropean Research Council (261101)


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