Mechanisms of Metabolic Dysfunction in Cancer- Associated Cachexia
Wagner, Erwin F
Genes and Development
Cold Spring Harbor Laboratory Press
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Petruzzelli, M., & Wagner, E. F. (2016). Mechanisms of Metabolic Dysfunction in Cancer- Associated Cachexia. Genes and Development https://www.repository.cam.ac.uk/handle/1810/253380
Metabolic dysfunction contributes to the clinical deterioration observed in advanced cancer patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the adipose tissue. This systemic syndrome, termed cancer-associated cachexia (CAC), is a major cause of morbidity and mortality. While once attributed solely to decreased food intake, the present description of cancer cachexia is a disorder of multi-organ energy imbalance. Here we review the molecules and pathways responsible for metabolic dysfunction in CAC and the ideas that led to the current understanding.
Cancer-associated cachexia (CAC), metabolic failure, white adipose tissue (WAT) browning, skeletal muscle atrophy
EFW is supported by a grant from the Spanish Ministry of Economy (BFU2012-40230) and a European Research Council Advanced Grant (ERC FCK/2008/37).
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Licence URL: http://creativecommons.org/licenses/by-nc/4.0/
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