Cross-talk between circadian clocks, sleep-wake cycles, and metabolic networks: Dispelling the darkness
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Ray, S., & Reddy, A. (2016). Cross-talk between circadian clocks, sleep-wake cycles, and metabolic networks: Dispelling the darkness. BioEssays, 38 394-405. https://doi.org/10.1002/bies.201500056
Integration of knowledge concerning circadian rhythms, metabolic networks, and sleep-wake cycles is imperative for unraveling the mysteries of biological cycles and their underlying mechanisms. During the last decade, enormous progress in circadian biology research has provided a plethora of new insights into the molecular architecture of circadian clocks. However, the recent identification of autonomous redox oscillations in cells has expanded our view of the clockwork beyond conventional transcription/translation feedback loop models, which have been dominant since the first circadian period mutants were identified in fruit fly. Consequently, non-transcriptional timekeeping mechanisms have been proposed, and the antioxidant peroxiredoxin proteins have been identified as conserved markers for 24-hour rhythms. Here, we review recent advances in our understanding of interdependencies amongst circadian rhythms, sleep homeostasis, redox cycles, and other cellular metabolic networks. We speculate that systems-level investigations implementing integrated multi-omics approaches could provide novel mechanistic insights into the connectivity between daily cycles and metabolic systems.
circadian rhythms, metabolic networks, non-transcriptional oscillator, peroxiredoxin, redox regulation, sleep-wake cycle, systems biology
ABR is a Wellcome Trust Senior Clinical Fellow and receives funding from the Wellcome Trust (Grant No. 100333/Z/12/Z), the European Research Council (ERC Starting Grant No. 281348, MetaCLOCK), the European Molecular Biology Organization (EMBO) Young Investigators Programme, and the Lister Institute of Preventative Medicine. SR is supported by the Wellcome Trust.
Wellcome Trust (100333/Z/12/Z)
European Research Council (281348)
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External DOI: https://doi.org/10.1002/bies.201500056
This record's URL: https://www.repository.cam.ac.uk/handle/1810/253453