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dc.contributor.authorMoffett, Ashleyen
dc.contributor.authorColucci, Francescoen
dc.date.accessioned2016-01-25T10:54:35Z
dc.date.available2016-01-25T10:54:35Z
dc.date.issued2015-08-18en
dc.identifier.citationMoffett & Colucci. Immunological Reviews Vol. 267, Issue 1, pp. 283-297. doi: 10.1111/imr.12323en
dc.identifier.issn0105-2896
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253461
dc.description.abstractAllogeneic individuals co-exist during pregnancy in eutherian mammals. Maternal and fetal cells intermingle at the site of placental attachment in the uterus, where the arteries are remodeled to supply the fetus with oxygen and nutrients. This access by placental cells to the maternal supply line determines the growth and birth weight of the baby and is subject to stabilizing selection. Invading placental trophoblast cells express human leukocyte antigen class I ligands (HLA-E, HLA-G, and HLA-C) for receptors on maternal uterine natural killer (NK) and myelomonocytic cells, CD94/NKG2, leukocyte immunoglobulin-like receptor (LILR), and killer immunoglobulin receptor (KIR). Of these, only the KIR/HLA-C system is highly polymorphic. Different combinations of maternal KIR and fetal HLA-C variants are correlated with low birth weight and pre-eclampsia or high birth weight and obstructed labor, the two extremes of the obstetric dilemma. This situation has arisen because of the evolution of bipedalism and subsequently, in the last million years, larger brains. At this point, the human system began to reach a balance between KIR A and KIR B haplotypes and C1 and C2 epitopes of HLA-C alleles that reflects a functional compromise between the competing demands of immunity and reproduction.
dc.description.sponsorshipWe are grateful for financial support from Centre for Trophoblast Research, University of Cambridge, King's College, Cambridge, and the Wellcome Trust.
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.subjectBirth weighten
dc.subjectKIRen
dc.subjectHLAen
dc.subjectTrophoblasten
dc.subjectPlacentaen
dc.titleCo-evolution of NK receptors and HLA ligands in humans is driven by reproductionen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1111/imr.12323en
prism.endingPage297
prism.publicationDate2015en
prism.publicationNameImmunological Reviewsen
prism.startingPage283
prism.volume267en
dc.rioxxterms.funderWellcome Trust
rioxxterms.versionofrecord10.1111/imr.12323en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-08-18en
dc.contributor.orcidMoffett, Ashley [0000-0002-8388-9073]
dc.contributor.orcidColucci, Francesco [0000-0001-5193-6376]
dc.identifier.eissn1600-065X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (085992/Z/08/Z)
pubs.funder-project-idBritish Heart Foundation (PG/09/077/27964)
rioxxterms.freetoread.startdate2016-08-18


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