Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer.
Neal, David E
Molecular & Cellular Oncology
Taylor & Francis
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Asim, M., Massie, C., & Neal, D. E. (2016). Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer.. Molecular & Cellular Oncology, 3 (3. e1140262)https://doi.org/10.1080/23723556.2016.1140262
To identify clinically relevant downstream effectors of androgen signaling, the androgen-regulated kinome was defined in prostate cancer (PCa). Within this study, choline kinase α (CHKA) was identified as an androgen receptor chaperone that is both a biomarker of progression and a potential therapeutic target for PCa.
Androgen Receptor, chaperones, prostate cancer, therapeutic target
External DOI: https://doi.org/10.1080/23723556.2016.1140262
This record's URL: https://www.repository.cam.ac.uk/handle/1810/253467