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dc.contributor.authorPalmer, William Jen
dc.contributor.authorDuarte, Anaen
dc.contributor.authorSchrader, Matthewen
dc.contributor.authorDay, Jonathanen
dc.contributor.authorKilner, Rebeccaen
dc.contributor.authorJiggins, Francisen
dc.date.accessioned2016-01-29T14:04:17Z
dc.date.available2016-01-29T14:04:17Z
dc.date.issued2016-01-27en
dc.identifier.citationW. J. Palmer et al. Proceedings of the Royal Society B - Biological Sciences (2016). volume 283, issue 1823: 283 20152733. DOI: 10.1098/rspb.2015.2733en
dc.identifier.issn0962-8452
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253556
dc.description.abstractSome group-living species exhibit social immunity, where the immune response of one individual can protect others in the group from infection. In burying beetles, this is part of parental care. Larvae feed on vertebrate carcasses which their parents smear with exudates that inhibit microbial growth. We have sequenced the transcriptome of the burying beetle Nicrophorus vespilloides and identified six genes that encode lysozymes—a type of antimicrobial enzyme that has previously been implicated in social immunity in burying beetles. When females start breeding and producing antimicrobial anal exudates, we found that the expression of one of these genes was increased by approximately 1000 times to become one of the most abundant transcripts in the transcriptome. Females varied considerably in the antimicrobial properties of their anal exudates, and this was strongly correlated with the expression of this lysozyme. We conclude that we have likely identified a gene encoding a key effector molecule in social immunity and that it was recruited during evolution from a function in personal immunity.
dc.description.sponsorshipThis work was funded by ERC grant DrosophilaInfection 281668 to F.M.J., NERC grant no. NE/H019731/1 to R.M.K., ERC grant BALDWINIAN_BEETLES 310785 to R.M.K. and a Wolfson Merit Award to R.M.K.
dc.languageEnglishen
dc.language.isoenen
dc.publisherRoyal Society Publishing
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectlysozymeen
dc.subjectsocial immunityen
dc.subjectburying beetleen
dc.subjectNicrophorusen
dc.subjectparental careen
dc.titleA gene associated with social immunity in the burying beetle Nicrophorus vespilloidesen
dc.typeArticle
dc.provenanceOA-6835
dc.description.versionThis is the final version of the article. It first appeared from Royal Society Publishing via https://doi.org/10.1098/rspb.2015.2733en
prism.number283 20152733en
prism.publicationDate2016en
prism.publicationNameProceedings of the Royal Society B - Biological Scienceen
prism.volume283en
dc.rioxxterms.funderNERC
dc.rioxxterms.projectidNE/H019731/1
dcterms.dateAccepted2016-01-05en
rioxxterms.versionofrecord10.1098/rspb.2015.2733en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-01-27en
dc.contributor.orcidDay, Jonathan [0000-0002-4386-3020]
dc.contributor.orcidKilner, Rebecca [0000-0003-1159-0758]
dc.contributor.orcidJiggins, Francis [0000-0001-7470-8157]
dc.identifier.eissn1471-2954
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idNERC (NE/H019731/1)
pubs.funder-project-idEuropean Research Council (281668)
pubs.funder-project-idEuropean Research Council (310785)
cam.orpheus.successThu Jan 30 12:55:20 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International