Show simple item record

dc.contributor.authorTimms, Richarden
dc.contributor.authorTchasovnikarova, Ivaen
dc.contributor.authorLehner, Paulen
dc.date.accessioned2016-02-02T10:42:57Z
dc.date.available2016-02-02T10:42:57Z
dc.date.issued2016-02-08en
dc.identifier.citationTimms et al. BioEssays (2016) Vol. 38, Issue 4, pp. 333-343. doi: 10.1002/bies.201500184en
dc.identifier.issn0265-9247
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253584
dc.description.abstractMuch of what we understand about heterochromatin formation in mammals has been extrapolated from forward genetic screens for modifiers of position-effect variegation (PEV) in the fruit fly Drosophila melanogaster. The recent identification of the HUSH (Human Silencing Hub) complex suggests that more recent evolutionary developments contribute to the mechanisms underlying PEV in human cells. Although HUSH-mediated repression also involves heterochromatin spreading through the reading and writing of the repressive H3K9me3 histone modification, clear orthologues of HUSH subunits are not found in Drosophila but are conserved in vertebrates. Here we compare the insights into the mechanisms of PEV derived from genetic screens in the fly, the mouse and in human cells, review what is currently known about the HUSH complex, and discuss the implications of HUSH-mediated silencing for viral latency. Future studies will provide mechanistic insight into HUSH complex function and reveal the relationship between HUSH and other epigenetic silencing complexes.
dc.description.sponsorshipThis work was funded by a Wellcome Trust Principal Research Fellowship to P.J.L. (084957/Z/08/Z) and a Wellcome Trust PhD studentship to I.A.T. The Cambridge Institute for Medical Research is in receipt of a Wellcome Trust Strategic Award.
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.titlePosition-effect variegation revisited: HUSHing up heterochromatin in human cellsen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1002/bies.201500184en
prism.endingPage343
prism.publicationDate2016en
prism.publicationNameBioEssaysen
prism.startingPage333
prism.volume38en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.projectid084957/Z/08/Z
rioxxterms.versionofrecord10.1002/bies.201500184en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-02-08en
dc.contributor.orcidTimms, Richard [0000-0001-7275-597X]
dc.contributor.orcidTchasovnikarova, Iva [0000-0002-0477-0956]
dc.contributor.orcidLehner, Paul [0000-0001-9383-1054]
dc.identifier.eissn1521-1878
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (101835/Z/13/Z)
pubs.funder-project-idWellcome Trust (084957/Z/08/Z)
rioxxterms.freetoread.startdate2017-02-08


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record