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dc.contributor.authorZhang, Jiaxiangen
dc.contributor.authorRittman, Timothyen
dc.contributor.authorNombela, Cristinaen
dc.contributor.authorFois, Alessandroen
dc.contributor.authorCoyle-Gilchrist, Ianen
dc.contributor.authorBarker, Rogeren
dc.contributor.authorHughes, Lauraen
dc.contributor.authorRowe, Jamesen
dc.date.accessioned2016-02-02T13:32:07Z
dc.date.available2016-02-02T13:32:07Z
dc.date.issued2015-11-18en
dc.identifier.citationJ. Zhang et al. Brain (2016). Volume 139, issue 1: pp. 161-173. DOI: 10.1093/brain/awv331en
dc.identifier.issn0006-8950
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253596
dc.description.abstractProgressive supranuclear palsy and Parkinson’s disease have distinct underlying neuropathology, but both diseases affect cognitive function in addition to causing a movement disorder. They impair response inhibition and may lead to impulsivity, which can occur even in the presence of profound akinesia and rigidity. The current study examined the mechanisms of cognitive impairments underlying disinhibition, using horizontal saccadic latencies that obviate the impact of limb slowness on executing response decisions. Nineteen patients with clinically diagnosed progressive supranuclear palsy (Richardson’s syndrome), 24 patients with clinically diagnosed Parkinson’s disease and 26 healthy control subjects completed a saccadic Go/No-Go task with a head-mounted infrared saccadometer. Participants were cued on each trial to make a pro-saccade to a horizontal target or withhold their responses. Both patient groups had impaired behavioural performance, with more commission errors than controls. Mean saccadic latencies were similar between all three groups. We analysed behavioural responses as a binary decision between Go and No-Go choices. By using Bayesian parameter estimation, we fitted a hierarchical drift–diffusion model to individual participants’ single trial data. The model decomposes saccadic latencies into parameters for the decision process: decision boundary, drift rate of accumulation, decision bias, and non-decision time. In a leave-one-out three-way classification analysis, the model parameters provided better discrimination between patients and controls than raw behavioural measures. Furthermore, the model revealed disease-specific deficits in the Go/No-Go decision process. Both patient groups had slower drift rate of accumulation, and shorter non-decision time than controls. But patients with progressive supranuclear palsy were strongly biased towards a pro-saccade decision boundary compared to Parkinson’s patients and controls. This indicates a prepotency of responding in combination with a reduction in further accumulation of evidence, which provides a parsimonious explanation for the apparently paradoxical combination of disinhibition and severe akinesia. The combination of the well-tolerated oculomotor paradigm and the sensitivity of the model-based analysis provides a valuable approach for interrogating decision-making processes in neurodegenerative disorders. The mechanistic differences underlying participants’ poor performance were not observable from classical analysis of behavioural data, but were clearly revealed by modelling. These differences provide a rational basis on which to develop and assess new therapeutic strategies for cognition and behaviour in these disorders.
dc.description.sponsorshipThis work was supported by Medical Research Council (MC-A060-5PQ30 and clinical training fellowship G1100464 to T.R.); Wellcome Trust (Senior fellowship to J.B.R. 103838 and joint award with MRC to the BCNI); Beverly Sackler scholarship to T.R.; the NIHR Cambridge Biomedical Research Centre including the Cambridge Brain bank; Parkinson’s UK; and the James F McDonnell Foundation 21st century science initiative on Understanding Human Cognition. A.F. was supported by University of Cambridge and East Anglia Foundation School.
dc.languageEnglishen
dc.language.isoenen
dc.publisherOxford University Press
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.subjectprogressive supranuclear palsyen
dc.subjectParkinson’s diseaseen
dc.subjectsaccadic inhibitionen
dc.subjectdrift-diffusion modelen
dc.subjectBayesian hierarchical modelen
dc.titleDifferent decision deficits impair response inhibition in progressive supranuclear palsy and Parkinson’s diseaseen
dc.typeArticle
dc.provenanceZD-13789
dc.description.versionThis is the final version of the article. It first appeared from Oxford University Press via http://dx.doi.org/10.1093/brain/awv331en
prism.endingPage173
prism.publicationDate2015en
prism.publicationNameBrainen
prism.startingPage161
dc.rioxxterms.funderMRC
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderNIHR
dc.rioxxterms.projectidMC-A060-5PQ30
dc.rioxxterms.projectidG1100464
dc.rioxxterms.projectid103838
dcterms.dateAccepted2015-09-29en
rioxxterms.versionofrecord10.1093/brain/awv331en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-11-18en
dc.contributor.orcidRittman, Timothy [0000-0003-1063-6937]
dc.contributor.orcidBarker, Roger [0000-0001-8843-7730]
dc.contributor.orcidHughes, Laura [0000-0002-1065-7175]
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.identifier.eissn1460-2156
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (G0001354)
pubs.funder-project-idMedical Research Council (G1100464)
pubs.funder-project-idWELLCOME TRUST (103838/Z/14/Z)
pubs.funder-project-idJames S McDonnell Foundation (220020289)
pubs.funder-project-idMedical Research Council (MC_U105597119)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales