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dc.contributor.authorPrentice, Philippaen
dc.contributor.authorOng, Kennethen
dc.contributor.authorSchoemaker, Marieke Hen
dc.contributor.authorvan, Tol Eric AFen
dc.contributor.authorVervoort, Jacquesen
dc.contributor.authorHughes, Ieuanen
dc.contributor.authorAcerini, Carloen
dc.contributor.authorDunger, Daviden
dc.date.accessioned2016-02-17T13:30:13Z
dc.date.available2016-02-17T13:30:13Z
dc.date.issued2016-02-10en
dc.identifier.citationPrentice et al. Acta Paediatrica (2016). doi: 10.1111/apa.13362en
dc.identifier.issn0803-5253
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253818
dc.description.abstractAim Benefits of human breast milk (HM) in avoiding rapid infancy weight-gain and later obesity could relate to its nutrient content. We tested the hypothesis that differential HM total calorie content (TCC) or macronutrient contents may be associated with infancy growth. Methods HM hindmilk samples were collected at ages 4-8 weeks from 614 mothers participating in a representative birth cohort, with repeated infancy anthropometry. HM triglyceride (fat), lipid analytes and lactose (carbohydrate) were measured by 1H-NMR, and protein content by the Dumas method. TCC and %macronutrients were determined. Results In 614 HM samples, fat content was: [median(IQR)]:2.6 (1.7-3.6)g/100mls, carbohydrate:8.6 (8.2-8.8)g/100mls, protein:1.2 (1.1-1.2)g/100mls; TCC:61.8 (53.7-71.3)kcal/100mls. HM of mothers exclusively breast-feeding vs. mixed-feeding was more calorific with higher %fat, lower %carbohydrate and lower %protein. Higher HM TCC was associated with lower 12m body mass index (BMI)/adiposity, and lower 3-12m gains in weight/BMI. HM %fat was inversely related to 3-12m gains in weight, BMI and adiposity, whereas %carbohydrate was positively related to these measures. HM %protein was positively related to 12m BMI. Conclusion HM analysis showed wide variation in %macronutrients. Although data on milk intakes were unavailable, our findings suggest functional relevance of HM milk composition to infant growth.
dc.description.sponsorshipPP was supported by a MRC Clinical Training Fellowship (G1001995). The Cambridge Baby Growth Study has been supported by the European Union, the World Cancer Research Foundation International, the Medical Research Council, the NIHR Cambridge Comprehensive Biomedical Research Centre, the Newlife Foundation for disabled children, the Mothercare Group Foundation, and Mead Johnson Nutrition.
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectbreast milken
dc.subjectmacronutrientsen
dc.subjectnutritionen
dc.subjectweighten
dc.subjectgrowthen
dc.titleBreast milk nutrient content and infancy growthen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Wiley via https://doi.org/ 10.1111/apa.13362en
prism.endingPage647
prism.publicationDate2016en
prism.startingPage641
prism.volume105en
dcterms.dateAccepted2016-02-08en
rioxxterms.versionofrecord10.1111/apa.13362en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-02-10en
dc.contributor.orcidOng, Kenneth [0000-0003-4689-7530]
dc.contributor.orcidAcerini, Carlo [0000-0003-2121-5871]
dc.contributor.orcidDunger, David [0000-0002-2566-9304]
dc.identifier.eissn1651-2227
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G1001995)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
pubs.funder-project-idMRC (MC_UU_12015/2)
pubs.funder-project-idMRC (G0600717B)
pubs.funder-project-idMedical Research Council (MC_U106179472)
cam.orpheus.successThu Jan 30 12:55:09 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International