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Mechanisms of oestrogen receptor (ER) gene regulation in breast cancer.


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Authors

Carroll, JS 

Abstract

Most breast cancers are driven by a transcription factor called oestrogen receptor (ER). Understanding the mechanisms of ER activity in breast cancer has been a major research interest and recent genomic advances have revealed extraordinary insights into how ER mediates gene transcription and what occurs during endocrine resistance. This review discusses our current understanding on ER activity, with an emphasis on several evolving, but important areas of ER biology.

Description

Keywords

Breast Neoplasms, Female, Gene Expression Regulation, Neoplastic, Humans, Receptors, Estrogen

Journal Title

Eur J Endocrinol

Conference Name

Journal ISSN

0804-4643
1479-683X

Volume Title

175

Publisher

Oxford University Press (OUP)
Sponsorship
Cancer Research UK (C14303/A17197)
Funding was from Cancer Research UK and the funding code is ‘core funding’.