Both mitochondrial DNA and mitonuclear gene mutations cause hearing loss through cochlear dysfunction.
Published version
Peer-reviewed
Repository URI
Repository DOI
Type
Article
Change log
Authors
Kullar, Peter J
Quail, Jenna
Lindsey, Phillip
Wilson, Janet A
Horvath, Rita https://orcid.org/0000-0002-9841-170X
Description
Keywords
DNA, Mitochondrial, Deafness, Hearing Loss, Hearing Loss, Sensorineural, Humans, Mitochondria, Mutation
Journal Title
Brain
Conference Name
Journal ISSN
0006-8950
1460-2156
1460-2156
Volume Title
139
Publisher
Oxford University Press (OUP)
Publisher DOI
Sponsorship
Wellcome Trust (101700/Z/13/Z)
Wellcome Trust (101876/Z/13/Z)
Wellcome Trust (101876/Z/13/Z)
PFC is a Wellcome Trust Senior Fellow in Clinical Science (101876/Z/13/Z), and a UK NIHR Senior Investigator, who receives support from the Medical Research Council Mitochondrial Biology Unit (MC_UP_1501/2), the Wellcome Trust Centre for Mitochondrial Research (096919Z/11/Z), the Medical Research Council (UK) Centre for Translational Muscle Disease research (G0601943), EU FP7 TIRCON, and the National Institute for Health Research (NIHR) Biomedical Research Centre based at Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge. PJK is a Wellcome Trust Clinical research fellow (101700/Z/13/Z). PYWM is supported by a Clinician Scientist Fellowship Award (G1002570) from the Medical Research Council (UK), and also receives funding from Fight for Sight (UK) and the UK National Institute of Health Research (NIHR) as part of the Rare Diseases Translational Research Collaboration. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. This study received support from the MRC Mitochondrial Disease Patient Cohort (http://mitocohort.ncl.ac.uk/).