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Both mitochondrial DNA and mitonuclear gene mutations cause hearing loss through cochlear dysfunction.

Published version
Peer-reviewed

Repository DOI


Change log

Authors

Kullar, Peter J 
Quail, Jenna 
Lindsey, Phillip 
Wilson, Janet A 

Description

Keywords

DNA, Mitochondrial, Deafness, Hearing Loss, Hearing Loss, Sensorineural, Humans, Mitochondria, Mutation

Journal Title

Brain

Conference Name

Journal ISSN

0006-8950
1460-2156

Volume Title

139

Publisher

Oxford University Press (OUP)
Sponsorship
Wellcome Trust (101700/Z/13/Z)
Wellcome Trust (101876/Z/13/Z)
PFC is a Wellcome Trust Senior Fellow in Clinical Science (101876/Z/13/Z), and a UK NIHR Senior Investigator, who receives support from the Medical Research Council Mitochondrial Biology Unit (MC_UP_1501/2), the Wellcome Trust Centre for Mitochondrial Research (096919Z/11/Z), the Medical Research Council (UK) Centre for Translational Muscle Disease research (G0601943), EU FP7 TIRCON, and the National Institute for Health Research (NIHR) Biomedical Research Centre based at Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge. PJK is a Wellcome Trust Clinical research fellow (101700/Z/13/Z). PYWM is supported by a Clinician Scientist Fellowship Award (G1002570) from the Medical Research Council (UK), and also receives funding from Fight for Sight (UK) and the UK National Institute of Health Research (NIHR) as part of the Rare Diseases Translational Research Collaboration. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. This study received support from the MRC Mitochondrial Disease Patient Cohort (http://mitocohort.ncl.ac.uk/).