Oxidative stress and the evolutionary origins of preeclampsia
Journal of Reproductive Immunology
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Elliot, M. (2016). Oxidative stress and the evolutionary origins of preeclampsia. Journal of Reproductive Immunology https://doi.org/10.1016/j.jri.2016.02.003
In this speculative paper, I consider the relationship between oxidative stress and the evolution of placentation in eutherian mammals. I argue that epitheliochorial placentation, in which fetal tissues remain separated from maternal blood throughout gestation, has evolved as a protective mechanism against oxidative stress arising from pregnancy, particularly in species with unusually long gestation periods and unusually large placentas. Human beings comprise an unusual species that has the life history characteristics of an epitheliochorial species, but exhibits hemochorial placentation, in which fetal tissues come into direct contact with maternal blood. I argue that the risk of preeclampsia has arisen as a consequence of the failure of human beings to evolve epitheliochorial placentation.
preeclampsia, hemochorial placentation, epitheliochorial placentation, oxidative stress
I thank Pierre-Yves Robillard for his kind hospitality, and participants in the International Workshops on Reproductive Immunology, Immunological Tolerance and Immunology of Preeclampsia, for their helpful comments and suggestions. I thank St. John’s College, Cambridge, for supporting my attendance at the workshop.
External DOI: https://doi.org/10.1016/j.jri.2016.02.003
This record's URL: https://www.repository.cam.ac.uk/handle/1810/254218
Attribution-NoDerivatives 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nd/4.0/
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