Moving forwards by blocking back-flow: the yin and yang of MI therapy
American Heart Association
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Pell, V. R., Chouchani, E. T., Murphy, M., Brookes, P. S., & Krieg, T. (2016). Moving forwards by blocking back-flow: the yin and yang of MI therapy. Circulation Research, 118 898-906. https://doi.org/10.1161/CIRCRESAHA.115.306569
Mitochondrial reactive oxygen species (ROS) production has emerged as an important pathological mechanism in myocardial ischemia/reperfusion (IR) injury. Attempts at targeting ROS by scavenging using antioxidants have however been clinically disappointing. This review will provide an overview of the current understanding of mitochondrial ROS in IR injury. We will outline novel therapeutic approaches designed to directly target the mitochondrial respiratory chain and prevent excessive ROS production and its associated pathology. This approach could lead to more effective interventions in an area where there is an urgent need for new treatments.
antioxidants, mitochondria, oxygen, reactive oxygen species, reperfusion injury
Work in our laboratories is supported by the Medical Research Council (UK) and the British Heart Foundation.
British Heart Foundation (PG/12/42/29655)
External DOI: https://doi.org/10.1161/CIRCRESAHA.115.306569
This record's URL: https://www.repository.cam.ac.uk/handle/1810/254279