Repository logo
 

tRNA fragments: novel players in intergenerational inheritance.

Accepted version
Peer-reviewed

Repository DOI


Change log

Authors

Gapp, Katharina 
Miska, Eric A 

Abstract

Non-genetic inheritance is an evocative topic; in the past few years, the debate around potential inheritance of life-time experiences independent of social factors in mammals has become highly prominent due to increasing evidence for phenotypes in the offspring after paternal environmental exposures. Strikingly, two independent studies published in Science newly implicate a special class of RNA, transfer RNA fragments, in the intergenerational effects of paternal dietary intervention.

Description

Keywords

Animals, Diet, High-Fat, Diet, Protein-Restricted, Epigenesis, Genetic, Mice, Paternal Inheritance, Phenotype, RNA, Transfer, Retroelements

Journal Title

Cell Res

Conference Name

Journal ISSN

1001-0602
1748-7838

Volume Title

26

Publisher

Springer Science and Business Media LLC
Sponsorship
Wellcome Trust (104640/Z/14/Z)