Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications
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Authors
Choudry, Fizzah Aziz
Abstract
Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriving clinical implications.
Description
Keywords
Journal Title
Stem Cells International
Conference Name
Journal ISSN
1687-966X
1687-9678
1687-9678
Volume Title
2016
Publisher
Hindawi
Publisher DOI
Sponsorship
MRC (MR/K024043/1)
EC FP7 NOE (282510)
EC FP7 NOE (282510)
Fizzah Aziz Choudry is recipient of an MRC clinical fellowship (MR/K024043/1). Mattia Frontini is supported by the BHF Cambridge Centre of Excellence [RE/13/6/30180] and EU-FP7 project BLUEPRINT (282510).