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dc.contributor.authorBarrett, Tristanen
dc.contributor.authorPriest, Andrew Nen
dc.contributor.authorLawrence, Edward Men
dc.contributor.authorGoldman, Debra Aen
dc.contributor.authorWarren, Anneen
dc.contributor.authorGnanapragasam, Vincenten
dc.contributor.authorSala, Evisen
dc.contributor.authorGallagher, Ferdiaen
dc.date.accessioned2016-03-15T12:17:17Z
dc.date.available2016-03-15T12:17:17Z
dc.date.issued2015-12-01en
dc.identifier.citationAmerican Journal of Roentgenology 2015, Volume 205, Number 6, W585-W593. DOI: 10.2214/AJR.15.14338en
dc.identifier.issn0361-803X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/254494
dc.description.abstractObjective: To investigate the ability of the apparent diffusion coefficient (ADC) ratio of tumor-to-normal prostate to overcome inherent variability based on choice of b-values, with whole-mount histopathology as a reference standard for tumor identification. Methods: Written informed consent was obtained from all patients for this institutional review board-approved study. Thirty-nine patients with prostate cancer underwent 3.0T-MRI, including diffusion-weighted imaging with b-values of 0, 150, 750 and 1,000 s/mm2. ADC maps were derived from four b-value combinations. Histological-derived regions-of-interest were defined for tumor and benign prostate to generate a ratio. The concordance correlation coefficient (CCC) was used to evaluate agreement and reproducibility at different b-values. Bland-Altman plots evaluated the pattern of relative measurement difference between b-value combinations. The ADC to Gleason score (GS) relationship was tested by Spearman rank correlation. Results: ADC values varied depending on the b-value combination selected. CCC was higher for ADC ratios (0.883; 95% CI 0.816-0.927) compared to absolute normal (0.873; 0.799-0.921) and tumor (0.792; 0.688-0.864) ADC values. The ADC ratio CCC for transition zone tumors was considerably higher in all cases. Bland-Altman analysis demonstrated higher variation for ADC maps incorporating a b-0 value for both ratio and absolute values. There was a stronger inverse relationship to GS for ADC ratios (rho: -0.35 to -0.46) compared to absolute ADC values (-0.12 to -0.38). Conclusion: The use of a simple ratio of tumor-to-normal prostate ADC improved concordance between different b-value combinations and could provide a more robust means of assessing restricted diffusion in the prostate.
dc.publisherAmerican Roentgen Ray Society
dc.titleThe ADC ratio of tumor to normal prostate as a method for quantifying diffusion weighted imaging of the prostateen
dc.title.alternativeRatio of Tumor to Normal Prostate Tissue Apparent Diffusion Coefficient as a Method for Quantifying DWI of the Prostate Read More: http://www.ajronline.org/doi/abs/10.2214/AJR.15.14338en
dc.typeArticle
dc.description.versionThis is a metadata record relating to an article that cannot be shared due to publisher copyright.en
prism.endingPageW593
prism.publicationDate2015en
prism.publicationNameAmerican Journal of Roentgenologyen
prism.startingPageW585
prism.volume205en
rioxxterms.versionofrecord10.2214/AJR.15.14338en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-12-01en
dc.contributor.orcidBarrett, Tristan [0000-0002-1180-1474]
dc.contributor.orcidWarren, Anne [0000-0002-1170-7867]
dc.contributor.orcidGnanapragasam, Vincent [0000-0003-4722-4207]
dc.contributor.orcidSala, Evis [0000-0002-5518-9360]
dc.contributor.orcidGallagher, Ferdia [0000-0003-4784-5230]
dc.identifier.eissn1546-3141
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (16628)
pubs.funder-project-idPROSTATE CANCER UK (PA14-012)


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