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dc.contributor.authorMedic, Nenaden
dc.contributor.authorZiauddeen, Hishamen
dc.contributor.authorErsche, Karenen
dc.contributor.authorFarooqi, Ismaaen
dc.contributor.authorBullmore, Edwarden
dc.contributor.authorNathan, Pradeep Jen
dc.contributor.authorRonan, Lisaen
dc.contributor.authorFletcher, Paulen
dc.date.accessioned2016-03-15T12:31:51Z
dc.date.available2016-03-15T12:31:51Z
dc.date.issued2016-03-22en
dc.identifier.citationMedic et al. International Journal of Obesity (2016) doi: 10.1038/ijo.2016.42en
dc.identifier.issn0307-0565
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/254496
dc.description.abstractBackground: While obesity is associated with structural changes in brain gray matter, findings have been inconsistent and the precise nature of these changes is unclear. Inconsistencies may partly be due to the use of different volumetric morphometry methods, and the inclusion of participants with comorbidities that exert independent effects on brain structure. The latter concern is particularly critical when sample sizes are modest. The purpose of the current study was to examine the relationship between cortical gray matter and body mass index (BMI), in healthy participants, excluding confounding comorbidities and using a large sample size. Subjects: 202 self-reported healthy volunteers were studied using surface-based morphometry, which permits the measurement of cortical thickness, surface area, and cortical folding, independent of each other. Results: While increasing BMI was not associated with global cortical changes, a more precise, region-based analysis revealed significant thinning of the cortex in two areas: left lateral occipital cortex (LOC) and right ventromedial prefrontal cortex (vmPFC). An analogous region-based analysis failed to find an association between BMI and regional surface area or folding. Participants’ age was also found to be negatively associated with cortical thickness of several brain regions, however, there was no overlap between age- and BMI-related effects on cortical thinning. Conclusions: Our data suggest that the key effect of increasing BMI on cortical gray matter is a focal thinning in the left LOC and right vmPFC. Consistent implications of the latter region in reward valuation and goal-control of decision and action suggests a possible shift in these processes with increasing BMI.
dc.description.sponsorshipWe thank all the participants and the staff of the Wolfson Brain Imaging Centre. This work was supported by the Bernard Wolfe Health Neuroscience Fund (NM, HZ, ISF, PCF), the Wellcome Trust (RGAG/144 to N.M, RGAG/188 to ISF, RNAG/259 to PCF) and the Medical Research Council (G0701497 to KDE).
dc.languageEnglishen
dc.language.isoenen
dc.publisherNature Publishing Group
dc.rightsAttribution 2.0 UK: England & Wales
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.subjectobesityen
dc.subjectsurface-based morphometryen
dc.subjectcortical thicknessen
dc.subjectventromedial prefrontal cortexen
dc.subjectlateral occipital cortexen
dc.titleIncreased Body Mass Index is Associated with Specific Regional Alterations in Brain Structureen
dc.title.alternativeAdiposity is Associated with Regional Cortical Thinningen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Nature Publishing Group via http://dx.doi.org/10.1038/ijo.2016.42.en
prism.endingPage1182
prism.publicationDate2016en
prism.publicationNameInternational Journal of Obesityen
prism.startingPage1177
prism.volume40en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderMRC
dc.rioxxterms.projectidRGAG/144
dc.rioxxterms.projectidRGAG/188
dc.rioxxterms.projectidRNAG/259
dc.rioxxterms.projectidG0701497
dcterms.dateAccepted2016-02-21en
rioxxterms.versionofrecord10.1038/ijo.2016.42en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-03-22en
dc.contributor.orcidZiauddeen, Hisham [0000-0003-4044-1719]
dc.contributor.orcidErsche, Karen [0000-0002-3203-1878]
dc.contributor.orcidFarooqi, Ismaa [0000-0001-7609-3504]
dc.contributor.orcidBullmore, Edward [0000-0002-8955-8283]
dc.contributor.orcidRonan, Lisa [0000-0001-8580-921X]
dc.contributor.orcidFletcher, Paul [0000-0001-8257-1517]
dc.identifier.eissn1476-5497
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G1000183)
pubs.funder-project-idMRC (G0701497)
pubs.funder-project-idWellcome Trust (095692/Z/11/Z)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)
pubs.funder-project-idWELLCOME TRUST (098497/Z/12/Z)
pubs.funder-project-idWellcome Trust (093568/Z/10/Z)
cam.orpheus.successThu Jan 30 12:54:52 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales