Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development
van, Marter Linda
van, Weissenbruch Mirjam
Ramenghi, Luca A
Smith, Lois EH
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Hellström, A., Ley, D., Hansen-Pupp, I., Hallberg, B., Löfqvist, C., van, M. L., van, W. M., et al. (2016). Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. Acta Paediatrica, 105 576-586. https://doi.org/10.1111/apa.13350
Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities.
development, foetus, insulin-like growth factor 1, metabolism, preterm infant
This work was supported by a European Commission FP7 project 305485 PREVENT-ROP grant to all of the authors.
External DOI: https://doi.org/10.1111/apa.13350
This record's URL: https://www.repository.cam.ac.uk/handle/1810/254510
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