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dc.contributor.authorSahakyan, Aleksandren
dc.contributor.authorBalasubramanian, Shankaren
dc.date.accessioned2016-03-17T17:08:06Z
dc.date.available2016-03-17T17:08:06Z
dc.date.issued2016-03-12en
dc.identifier.citationSahakyan & Balasubramanian. BMC Genomics (2016) Vol. 17:225. doi: 10.1186/s12864-016-2582-9en
dc.identifier.issn1471-2164
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/254554
dc.description.abstractBackground The role of random mutations and genetic errors in defining the etiology of cancer and other multigenic diseases has recently received much attention. With the view that complex genes should be particularly vulnerable to such events, here we explore the link between the simple properties of the human genes, such as transcript length, number of splice variants, exon/intron composition, and their involvement in the pathways linked to cancer and other multigenic diseases. Results We reveal a substantial enrichment of cancer pathways with long genes and genes that have multiple splice variants. Although the latter two factors are interdependent, we show that the overall gene length and splicing complexity increase in cancer pathways in a partially decoupled manner. Our systematic survey for the pathways enriched with top lengthy genes and with genes that have multiple splice variants reveal, along with cancer pathways, the pathways involved in various neuronal processes, cardiomyopathies and type II diabetes. We outline a correlation between the gene length and the number of somatic mutations. Conclusions Our work is a step forward in the assessment of the role of simple gene characteristics in cancer and a wider range of multigenic diseases. We demonstrate a significant accumulation of long genes and genes with multiple splice variants in pathways of multigenic diseases that have already been associated with de novo mutations. Unlike the cancer pathways, we note that the pathways of neuronal processes, cardiomyopathies and type II diabetes contain genes long enough for topoisomerase-dependent gene expression to also be a potential contributing factor in the emergence of pathologies, should topoisomerases become impaired.
dc.description.sponsorshipThis research was supported by the Cancer Research UK and the Herchel Smith Fund. SB is a Wellcome Trust Senior Investigator.
dc.languageEnglishen
dc.language.isoenen
dc.publisherBioMed Central
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.subjectlong genesen
dc.subjectsplice variantsen
dc.subjectcanceren
dc.subjectmultigenic diseasesen
dc.subjectKEGG pathwaysen
dc.subjectmutationsen
dc.subjecttopoisomerasesen
dc.titleLong genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseasesen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from BioMed Central via http://dx.doi.org/10.1186/s12864-016-2582-9en
prism.number225en
prism.publicationDate2016en
prism.publicationNameBMC Genomicsen
prism.volume17en
dc.rioxxterms.funderCRUK
dc.rioxxterms.funderWellcome Trust
dcterms.dateAccepted2016-03-08en
rioxxterms.versionofrecord10.1186/s12864-016-2582-9en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-03-12en
dc.contributor.orcidSahakyan, Aleksandr [0000-0002-8343-3594]
dc.contributor.orcidBalasubramanian, Shankar [0000-0002-0281-5815]
dc.identifier.eissn1471-2164
rioxxterms.typeJournal Article/Reviewen


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales