How the newborn centriole becomes a mother.
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Fu, J., & Glover, D. (2016). How the newborn centriole becomes a mother.. Cell Cycle, 15 (12), 1521-1522. https://doi.org/10.1080/15384101.2016.1164566
The centriole is a conserved organelle in most animal cells. It is built with numerous proteins including a 9-fold symmetrical microtubule wall. Centrioles usually exist in pairs and constitute the core of the centrosome, the major microtubule-organizing center of the cell. In line with DNA replication, the centriole duplicates once every cell cycle. Beginning in G1 phase, a newly born daughter centriole assembles perpendicularly to the mother centriole, and subsequently elongates throughout S and G2. Interestingly, the daughter centriole can neither duplicate itself nor nucleate pericentriolar material (PCM), a cloud of proteins that enhances the microtubule nucleating ability of the centrosome, until the centriole has passed through mitosis.1-3 This process enabling the daughter centriole to acquire motherhood and be able to duplicate and recruit PCM has been named “centriole-to-centrosome conversion”.1 In a recent study, we demonstrated that centriole-to-centrosome conversion relies upon the building of a protein complex comprising Cep135, Ana1/Cep295 and Asl/Cep152 onto the nascent centriole in both Drosophila melanogaster and human cells.4
Ana1, Asterless, Cep135, Cep152, Cep295, centriole, centrosome, conversion, Cell Cycle Proteins, Centrioles
External DOI: https://doi.org/10.1080/15384101.2016.1164566
This record's URL: https://www.repository.cam.ac.uk/handle/1810/254595