Old cells, new tricks: chromatin structure in senescence
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Parry, A., & Narita, M. (2016). Old cells, new tricks: chromatin structure in senescence. Mammalian Genome https://www.repository.cam.ac.uk/handle/1810/254618
Cellular senescence is a stable form of cell cycle arrest with roles in many pathophysiological processes including development, tissue repair, cancer and aging. Senescence does not represent a single entity but rather a heterogeneous phenotype that depends on the trigger and cell type of origin. Such heterogeneous features include alterations to chromatin structure and epigenetic states. New technologies are beginning to unravel the distinct mechanisms regulating chromatin structure during senescence. Here we describe the multiple levels of chromatin organization associated with senescence: global and focal, linear and higher order.
The University of Cambridge, Cancer Research UK and Hutchison Whampoa supported this work.
Cancer Research UK (C14303_do not transfer)
This record's URL: https://www.repository.cam.ac.uk/handle/1810/254618