Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification
Cork, David G
ACS Sustainable Chemistry & Engineering
American Chemical Society
MetadataShow full item record
Ouchi, T., Mutton, R., Rojas, V., Fitzpatrick, D., Cork, D. G., Battilocchio, C., & Ley, S. (2016). Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification. ACS Sustainable Chemistry & Engineering, 4 1912-1916. https://doi.org/10.1021/acssuschemeng.6b00287
A solvent-free approach to intensification of chemical processes is reported. This concept, in which reactions are carried out solvent-free, without the need for further downstream processing, was highlighted first with a full reduction of ethyl nicotinate to ethylpiperidine-3-carboxylate under continuous flow conditions. Using a small footprint reactor, a throughput of 26.4 g h–1 was achieved. Similarly, this approach was used for the telescoped two-step synthesis of 2-propyl phenol (productivity 120 g h–1) and 2-propyl cyclohexanone (productivity 30 g h–1), starting from the commercially available allyl phenol ether via Claisen rearrangement and subsequent reduction.
Claisen rearrangement, flow chemistry, heterogeneous hydrogenation, process intensification, solvent-free reactions
We would like to thank Pfizer Worldwide Research & Development (CB), the EPSRC (RJM, SVL, Grant Codes EP/K009494/1, EP/M004120/1 and EP/K039520/1) and the Woolf Fisher Trust (DEF) for financial support.
Embargo Lift Date
External DOI: https://doi.org/10.1021/acssuschemeng.6b00287
This record's URL: https://www.repository.cam.ac.uk/handle/1810/254647