Feasibility of Using 2,3,3,3-Tetrafluoropropene (R1234yf) as a Solvent for Solid–Liquid Extraction of Biopharmaceuticals
ACS Sustainable Chemistry & Engineering
American Chemical Society
MetadataShow full item record
Suberu, J., Yamin, P., Cornell, R., Sam, A., & Lapkin, A. (2016). Feasibility of Using 2,3,3,3-Tetrafluoropropene (R1234yf) as a Solvent for Solid–Liquid Extraction of Biopharmaceuticals. ACS Sustainable Chemistry & Engineering, 4 (5), 2559-2568. https://doi.org/10.1021/acssuschemeng.5b01721
Tetrafluoropropene (R1234yf) is the most likely replacement for tetrafluoroethane (R134a), a widely used refrigerant, propellant and solvent, characterised by very high global warming potential. In this study solvation properties of R1234yf were studied experimentally and computationally for solubility of artemisinin, a precursor to the important bio-pharmaceutical API, and extraction of artemisinin from biomass. R1234yf was shown to be a poorer solvent than R134a for artemisinin. COSMO-RS calculations of solvation in R1234yf suggest that the decrease in performance is likely to be due to entropic effects. However, R1234yf was effectively used in solid liquid extraction of Artemisia annua. The new solvent has shown an increased selectivity to the target metabolite artemisinin. This should allow for design of more selective separation processes based on the new solvent molecule with a low global warming potential of 4 relative to CO2.
artemisinin, COSMO-RS, extraction, R1234yf, R134a, solubility
This work was funded under iCON feasibility projects scheme of EPSRC “Centre for Continuous Manufacturing (CMAC)”, EP/IO33459/1. We acknowledge past funding from Medicine for Malaria Ventures for HPLC instrument and funding by University of Cambridge for the LCMS system.
EPSRC (via University of Strathclyde) (unknown)
Embargo Lift Date
External DOI: https://doi.org/10.1021/acssuschemeng.5b01721
This record's URL: https://www.repository.cam.ac.uk/handle/1810/254668