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dc.contributor.authorSuberu, Jen
dc.contributor.authorYamin, Pen
dc.contributor.authorCornell, Ren
dc.contributor.authorSam, Aen
dc.contributor.authorLapkin, Alexeien
dc.date.accessioned2016-03-24T12:49:03Z
dc.date.available2016-03-24T12:49:03Z
dc.date.issued2016-05-02en
dc.identifier.citationSuberu et al. ACS Sustainable Chemistry & Engineering (2016). doi: 10.1021/acssuschemeng.5b01721en
dc.identifier.issn2168-0485
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/254668
dc.description.abstractTetrafluoropropene (R1234yf) is the most likely replacement for tetrafluoroethane (R134a), a widely used refrigerant, propellant, and solvent, characterized by a very high global warming potential. In this study, solvation properties of R1234yf were studied experimentally and computationally for solubility of artemisinin, a precursor to the important biopharmaceutical API, and extraction of artemisinin from biomass. R1234yf was shown to be a poorer solvent than R134a for artemisinin. COSMO-RS calculations of solvation in R1234yf suggest that the decrease in performance is likely due to entropic effects. However, R1234yf was effectively used in solid–liquid extraction of Artemisia annua. The new solvent has shown an increased selectivity to the target metabolite artemisinin. This should allow for design of more selective separation processes based on the new solvent molecule with a low global warming potential of 4 relative to CO2.
dc.language.isoenen
dc.publisherAmerican Chemical Society
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectartemisininen
dc.subjectCOSMO-RSen
dc.subjectextractionen
dc.subjectR1234yfen
dc.subjectR134aen
dc.subjectsolubilityen
dc.titleFeasibility of Using 2,3,3,3-Tetrafluoropropene (R1234yf) as a Solvent for Solid–Liquid Extraction of Biopharmaceuticalsen
dc.typeArticle
prism.endingPage2568
prism.issueIdentifier5en
prism.publicationDate2016en
prism.publicationNameACS Sustainable Chemistry & Engineeringen
prism.startingPage2559
prism.volume4en
dc.rioxxterms.funderEPSRC
dc.rioxxterms.projectidEP/IO33459/1
dcterms.dateAccepted2016-02-26en
rioxxterms.versionofrecord10.1021/acssuschemeng.5b01721en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-05-02en
dc.contributor.orcidLapkin, Alexei [0000-0001-7621-0889]
dc.identifier.eissn2168-0485
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (via University of Strathclyde) (unknown)
cam.issuedOnline2017-03-17en
cam.orpheus.successThu Jan 30 12:54:45 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International