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dc.contributor.authorPeco, Emilieen
dc.contributor.authorDavla, Sejalen
dc.contributor.authorCamp, Dariusen
dc.contributor.authorStacey, Stephanie Men
dc.contributor.authorLandgraf, Matthiasen
dc.contributor.authorvan, Meyel Don Jen
dc.date.accessioned2016-04-05T11:45:51Z
dc.date.available2016-04-05T11:45:51Z
dc.date.issued2016-02-18en
dc.identifier.citationPeco et al. Development (2016) Vol. 143, pp. 1170-1181. doi: 10.1242/dev.133165en
dc.identifier.issn0950-1991
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/254794
dc.description.abstractAstrocytes are crucial in the formation, fine-tuning, function and plasticity of neural circuits in the central nervous system. However, important questions remain about the mechanisms instructing astrocyte cell fate. We have studied astrogenesis in the ventral nerve cord of Drosophila larvae, where astrocytes exhibit remarkable morphological and molecular similarities to those in mammals. We reveal the births of larval astrocytes from a multipotent glial lineage, their allocation to reproducible positions, and their deployment of ramified arbors to cover specific neuropil territories to form a stereotyped astroglial map. Finally, we unraveled a molecular pathway for astrocyte differentiation in which the Ets protein Pointed and the Notch signaling pathway are required for astrogenesis; however, only Notch is sufficient to direct non-astrocytic progenitors toward astrocytic fate. We found that Prospero is a key effector of Notch in this process. Our data identify an instructive astrogenic program that acts as a binary switch to distinguish astrocytes from other glial cells.
dc.description.sponsorshipThis work was supported by grants from the Canadian Institutes of Health Research (CIHR) and the Canada Foundation for Innovation (CFI) to D.J.v.M.; by a Biotechnology and Biological Sciences Research Council (UK) grant [BB/I022414/1] to M.L.; and by studentship awards to S.D. from McGill University (Max Stern) and the Integrated Program in Neuroscience.
dc.languageEnglishen
dc.language.isoenen
dc.publisherThe Company of Biologists
dc.subjectastrocyte developmenten
dc.subjectastroglial mapen
dc.subjectNotchen
dc.subjectPointeden
dc.subjectProsperoen
dc.titleDrosophila astrocytes cover specific territories of the CNS neuropil and are instructed to differentiate by Prospero, a key effector of Notchen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from the Company of Biologists via http://dx.doi.org/10.1242/dev.133165en
prism.endingPage1181
prism.publicationDate2016en
prism.publicationNameDevelopmenten
prism.startingPage1170
prism.volume143en
dc.rioxxterms.funderBBSRC
dc.rioxxterms.projectidBB/I022414/1
dcterms.dateAccepted2016-02-08en
rioxxterms.versionofrecord10.1242/dev.133165en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-02-18en
dc.contributor.orcidLandgraf, Matthias [0000-0001-5142-1997]
dc.identifier.eissn1477-9129
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/I022414/1)
rioxxterms.freetoread.startdate2016-08-18


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