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dc.contributor.authorFushiki, Akira
dc.contributor.authorZwart, Maarten F
dc.contributor.authorKohsaka, Hiroshi
dc.contributor.authorFetter, Richard D
dc.contributor.authorCardona, Albert
dc.contributor.authorNose, Akinao
dc.date.accessioned2016-04-06T15:36:22Z
dc.date.available2016-04-06T15:36:22Z
dc.date.issued2016-02-15
dc.identifier.citationA. Fushiki et al. eLife (2016). volume 5, e13253. DOI: 10.7554/eLife.13253
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/254840
dc.description.abstractAnimals move by adaptively coordinating the sequential activation of muscles. The circuit mechanisms underlying coordinated locomotion are poorly understood. Here, we report on a novel circuit for the propagation of waves of muscle contraction, using the peristaltic locomotion of Drosophila larvae as a model system. We found an intersegmental chain of synaptically connected neurons, alternating excitatory and inhibitory, necessary for wave propagation and active in phase with the wave. The excitatory neurons (A27h) are premotor and necessary only for forward locomotion, and are modulated by stretch receptors and descending inputs. The inhibitory neurons (GDL) are necessary for both forward and backward locomotion, suggestive of different yet coupled central pattern generators, and its inhibition is necessary for wave propagation. The circuit structure and functional imaging indicated that the commands to contract one segment promote the relaxation of the next segment, revealing a mechanism for wave propagation in peristaltic locomotion.
dc.description.sponsorshipWe thank the Fly EM Project Team at HHMI Janelia for the gift of the EM volume, the HHMI visa office, and HHMI Janelia for funding.
dc.languageEnglish
dc.language.isoen
dc.publishereLife Sciences Publications, Ltd
dc.rightsAttribution 2.0 UK: England & Wales
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.titleA circuit mechanism for the propagation of waves of muscle contraction in Drosophila.
dc.typeArticle
dc.provenanceOA-7967
dc.description.versionThis is the final version of the article. It first appeared from eLife via http://dx.doi.org/10.7554/eLife.13253
prism.numbere13253
prism.publicationDate2016
prism.publicationNameElife
prism.volume5
dcterms.dateAccepted2016-02-14
rioxxterms.versionofrecord10.7554/eLife.13253
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-02-15
dc.contributor.orcidCardona, Albert [0000-0003-4941-6536]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Review
cam.issuedOnline2016-02-15


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales