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dc.contributor.authorRaffan, Eleanoren
dc.contributor.authorDennis, Rowena Jen
dc.contributor.authorO'Donovan, Conor Jen
dc.contributor.authorBecker, Julia Men
dc.contributor.authorScott, Roberten
dc.contributor.authorSmith, Stephenen
dc.contributor.authorWithers, David Jen
dc.contributor.authorWood, Claire Jen
dc.contributor.authorConci, Elenaen
dc.contributor.authorClements, Dylan Nen
dc.contributor.authorSummers, Kim Men
dc.contributor.authorGerman, Alexander Jen
dc.contributor.authorMellersh, Cathrynen
dc.contributor.authorArendt, Maja Len
dc.contributor.authorIyemere, Valentine Pen
dc.contributor.authorWithers, Elaineen
dc.contributor.authorSöder, Josefinen
dc.contributor.authorWernersson, Saraen
dc.contributor.authorAndersson, Göranen
dc.contributor.authorLindblad-Toh, Kerstinen
dc.contributor.authorYeo, Gilesen
dc.contributor.authorO'Rahilly, Stephenen
dc.date.accessioned2016-04-12T13:40:14Z
dc.date.available2016-04-12T13:40:14Z
dc.date.issued2016-05-03en
dc.identifier.issn1550-4131
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/254921
dc.description.abstractSequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.
dc.description.sponsorshipWe are grateful to Rachel Moxon of Guide Dogs UK for collecting the assistance dog samples; Stephen J Sharp of the MRC Epidemiology Unit for his statistical advice; Jens Häggström, Karin Hultin Jäderlund and Berndt Klingeborn for the Swedish dog samples; Anne White for efforts to develop a canine beta MSH assay and adaptation of her original for figure 1b; and the Dogslife Consortium for samples from British Labrador retrievers (supported by an Institute Core Strategic Grant from the BBSRC to the Roslin Institute). A full list of the investigators who contributed to the Dogslife project is available from www.dogslife.ac.uk/who-runs-dogslife. AJG's academic post at the University of Liverpool is financially supported by Royal Canin. The work was primarily supported by the Wellcome Trust (Senior Investigator Award 095515/Z/11/Z and Strategic Award 100574/Z/12/Z), MRC (MRC Metabolic Diseases Unit, award 4050281695 and MRC_MC_UU_12012/5), and Dogs Trust. The authors would like to thank all the veterinary surgeons and nurses, owners and dogs who contributed samples.
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution 4.0 International*
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleA Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogsen
dc.typeArticle
dc.provenanceOA-8156
dc.description.versionThis is the final version of the article. It first appeared from Elsevier via https://doi.org/10.1016/j.cmet.2016.04.012en
prism.endingPage900
prism.publicationDate2016en
prism.publicationNameCell Metabolismen
prism.startingPage893
prism.volume23en
dc.rioxxterms.funderBBSRC
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderMRC
dc.rioxxterms.projectid095515/Z/11/Z
dc.rioxxterms.projectid100574/Z/12/Z
dc.rioxxterms.projectid4050281695
dc.rioxxterms.projectidMRC_MC_UU_12012/5
dcterms.dateAccepted2016-04-13en
rioxxterms.versionofrecord10.1016/j.cmet.2016.04.012en
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-05-03en
dc.contributor.orcidRaffan, Eleanor [0000-0002-1403-3538]
dc.contributor.orcidSmith, Stephen [0000-0001-7744-3238]
dc.contributor.orcidMellersh, Cathryn [0000-0002-2336-0370]
dc.contributor.orcidYeo, Giles [0000-0001-8823-3615]
dc.contributor.orcidO'Rahilly, Stephen [0000-0003-2199-4449]
dc.identifier.eissn1932-7420
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (095515/Z/11/Z)
pubs.funder-project-idWellcome Trust (100574/Z/12/Z)
pubs.funder-project-idMRC (MC_UU_12012/5)
pubs.funder-project-idMRC (MC_UU_12012/1)
cam.orpheus.successThu Jan 30 12:54:32 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International