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Long-term physical activity: an exogenous risk factor for sporadic amyotrophic lateral sclerosis?

Published version
Peer-reviewed

Repository DOI


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Authors

Harwood, Ceryl A 
Gunstone, Sue 
Wareham, Nicholas J 

Abstract

OBJECTIVES: To conduct a geographically defined, UK-based case-control study, to examine any association between physical activity (PA) and amyotrophic lateral sclerosis (ALS). METHODS: A novel historical PA questionnaire was designed, validated, and subsequently administered in individual face-to-face interviews of 175 newly diagnosed sporadic ALS cases and 317 age- and sex-matched community controls. Historical PA energy expenditure and time spent in vigorous-intensity PA were derived from questionnaire data and compared between cases and controls. RESULTS: Participation in an extra 10kJ/kg/day of PA (equivalent to approximately 45minutes brisk walking) was consistently associated with an increased risk of ALS, with the strongest association observed for adulthood exercise-related PA (OR 1.47, 95% CI 1.10-1.97). An extra 10mins/day of vigorous PA was also associated with the odds of ALS (OR 1.03, 95% CI 1·01-1·05). Results were slightly attenuated following adjustment for smoking and educational attainment. CONCLUSIONS: To our knowledge this is the first study to demonstrate a positive association between ALS and PA participation using a specifically designed and validated historical PA questionnaire. Despite the well-established health benefits of PA, a high activity lifestyle may also be associated with elevated risk of ALS. Large-scale prospective studies in the future may help to confirm this association.

Description

Keywords

Amyotrophic lateral sclerosis, Epidemiology, Gene-environment interaction, Physical Activity, Risk factor, Adult, Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis, Case-Control Studies, Exercise, Female, Humans, Longitudinal Studies, Male, Middle Aged, Odds Ratio, Retrospective Studies, Risk Factors, Surveys and Questionnaires, United Kingdom

Journal Title

Amyotroph Lateral Scler Frontotemporal Degener

Conference Name

Journal ISSN

2167-8421
2167-9223

Volume Title

17

Publisher

Informa UK Limited
Sponsorship
MRC (MC_PC_13048)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
Medical Research Council (MC_UU_12015/1)
Medical Research Council (MC_UU_12015/3)
Medical Research Council (MC_U106179471)
Medical Research Council (MC_U106179473)
This study was funded by a Medical Research Council/Motor Neurone Disease Association Lady Edith Wolfson Fellowship.