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dc.contributor.authorChen, Maxine Men
dc.contributor.authorO'Mara, Tracy Aen
dc.contributor.authorNunn, Deborahen
dc.contributor.authorPainter, Jodie Nen
dc.contributor.authorThe, Australian National Endometrial Cancer Study Group ANECSen
dc.contributor.authorAttia, Johnen
dc.contributor.authorBlack, Amandaen
dc.contributor.authorBrinton, Louiseen
dc.contributor.authorChanock, Stephenen
dc.contributor.authorChen, Chuen
dc.contributor.authorCheng, Timothy HTen
dc.contributor.authorCook, Linda Sen
dc.contributor.authorCrous-Bou, Martaen
dc.contributor.authorDoherty, Jenniferen
dc.contributor.authorFriedenreich, Christine Men
dc.contributor.authorGarcia-Closas, Montserraten
dc.contributor.authorGaudet, Mia Men
dc.contributor.authorGorman, Maggieen
dc.contributor.authorHaiman, Christopheren
dc.contributor.authorHankinson, Susan Een
dc.contributor.authorHartge, Patriciaen
dc.contributor.authorHenderson, Brian Een
dc.contributor.authorHodgson, Shirleyen
dc.contributor.authorHolliday, Elizabeth Gen
dc.contributor.authorHorn-Ross, Pamela Len
dc.contributor.authorHunter, David Jen
dc.contributor.authorLe, Marchand Loicen
dc.contributor.authorLiang, Xiaolinen
dc.contributor.authorLissowska, Jolantaen
dc.contributor.authorLong, Jirongen
dc.contributor.authorLu, Lingengen
dc.contributor.authorMagliocco, Anthony Men
dc.contributor.authorMartin, Lynnen
dc.contributor.authorMcEvoy, Marken
dc.contributor.authorNational, Study of Endometrial Cancer Genetics Group NSECGen
dc.contributor.authorOlson, Sara Hen
dc.contributor.authorOrlow, Ireneen
dc.contributor.authorPooler, Loreallen
dc.contributor.authorPrescott, Jenniferen
dc.contributor.authorRastogi, Radhaien
dc.contributor.authorRebbeck, Timothy Ren
dc.contributor.authorRisch, Harveyen
dc.contributor.authorSacerdote, Carlottaen
dc.contributor.authorSchumacher, Fredericken
dc.contributor.authorSetiawan, Veronica Wendyen
dc.contributor.authorScott, Rodney Jen
dc.contributor.authorSheng, Xinen
dc.contributor.authorShu, Xiaoouen
dc.contributor.authorTurman, Constanceen
dc.contributor.authorVan, Den Berg Daviden
dc.contributor.authorWang, Zhaomingen
dc.contributor.authorWeiss, Noel Sen
dc.contributor.authorWentzensen, Nicholasen
dc.contributor.authorXia, Lucyen
dc.contributor.authorXiang, Yong-Bingen
dc.contributor.authorYang, Hannah Pen
dc.contributor.authorYu, Herberten
dc.contributor.authorZhang, Weien
dc.contributor.authorPharoah, Paulen
dc.contributor.authorDunning, Alisonen
dc.contributor.authorTomlinson, Ianen
dc.contributor.authorEaston, Douglasen
dc.contributor.authorKraft, Peteren
dc.contributor.authorSpurdle, Amanda Ben
dc.contributor.authorDe, Vivo Immaculataen
dc.date.accessioned2016-04-15T11:55:50Z
dc.date.available2016-04-15T11:55:50Z
dc.date.issued2016-03-23en
dc.identifier.citationM. M. Chen et al. Human Molecular Genetics (2016). DOI: 10.1093/hmg/ddw092en
dc.identifier.issn0964-6906
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/254999
dc.description.abstractEndometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four GWAS (4,907 cases and 11,945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10⁻⁸) at 6p22.3 (rs1740828; P = 2.29 × 10⁻⁸, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.
dc.description.sponsorshipCRUK, Wellcome Trust, and numerous other funders. See manuscript for a complete list.
dc.languageEnglishen
dc.language.isoenen
dc.publisherOxford University Press
dc.titleGWAS meta-analysis of 16,852 women identifies new susceptibility locus for endometrial cancer.en
dc.typeArticle
dc.provenanceOA-8245
dc.description.versionThis is the author accepted manuscript. The final version is available from Oxford Universe Press via http://dx.doi.org/10.1093/hmg/ddw092en
prism.publicationDate2016en
prism.publicationNameHuman Molecular Geneticsen
dc.rioxxterms.funderCRUK
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderMultiple - see manuscript acknowledgements
dcterms.dateAccepted2016-03-15en
rioxxterms.versionofrecord10.1093/hmg/ddw092en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-03-23en
dc.contributor.orcidNunn, Deborah [0000-0003-1465-5799]
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.contributor.orcidDunning, Alison [0000-0001-6651-7166]
dc.contributor.orcidEaston, Douglas [0000-0003-2444-3247]
dc.identifier.eissn1460-2083
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (10124)
pubs.funder-project-idCancer Research UK (16561)
rioxxterms.freetoread.startdate2017-03-23


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