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dc.contributor.authorMcBride, OMBen
dc.contributor.authorJoshi, NVen
dc.contributor.authorRobson, JMJen
dc.contributor.authorMacGillivray, TJen
dc.contributor.authorGray, CDen
dc.contributor.authorFletcher, AMen
dc.contributor.authorDweck, MRen
dc.contributor.authorvan, Beek EJRen
dc.contributor.authorRudd, Jamesen
dc.contributor.authorNewby, DEen
dc.contributor.authorSemple, SIen
dc.identifier.citationMcBride et al. European Journal of Vascular and Endovascular Surgery (2016), 51(4), pp. 518–526. doi: 10.1016/j.ejvs.2015.12.018en
dc.description.abstractObjectives: Inflammation is critical in the pathogenesis of abdominal aortic aneurysm (AAA) disease. Combined 18F-fludeoxyglucose (18F-FDG) positron emission tomography with computed tomography (PET-CT) and ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI) are non-invasive methods of assessing tissue inflammation. The aim of this study was to compare these techniques in patients with AAA. Materials and methods: Fifteen patients with asymptomatic AAA with diameter 46 +/- 7 mm underwent PET-CT with 18F-FDG, and T2*-weighted MRI before and 24 hours after administration of USPIO. The PET-CT and MRI data were then co-registered. Standardised uptake values (SUVs) were calculated to measure 18F-FDG activity, and USPIO uptake was determined using the change in R2*. Comparisons between the techniques were made using a quadrant analysis and a voxel-by-voxel evaluation. Results: When all areas of the aneurysm were evaluated, there was a modest correlation between the SUV on PET-CT and the change in R2* on USPIO-enhanced MRI (n ¼ 70,345 voxels; r ¼ .30; p < .0001). Although regions of increased 18F-FDG and USPIO uptake co-localised on occasion, this was infrequent (kappa statistic 0.074; 95% CI 0.026e0.122). 18F-FDG activity was commonly focused in the shoulder region whereas USPIO uptake was more apparent in the main body of the aneurysm. Maximum SUV was lower in patients with mural USPIO uptake. Conclusions: Both 18F-FDG PET-CT and USPIO-MRI uptake identify vascular inflammation associated with AAA. Although they demonstrate a modest correlation, there are distinct differences in the pattern and distribution of uptake, suggesting a differential detection of macrophage glycolytic and phagocytic activity respectively.
dc.description.sponsorshipThis research was supported by grants from the National Institutes of Health Research (NIHR) Efficacy and Mechanism Evaluation Programme (11/20/03), the British Heart Foundation (PG/09/083) and the Evelyn Trust (09/22). Dr. McBride is supported by the Academic Department of Military Surgery and Trauma, Royal Centre for Defence Medicine. Dr. Joshi is supported by Chief Scientist Office (ETM/160). Dr. van Beek is supported by the Scottish Imaging Network e a Platform of Scientific Excellence. The work of Dr. Rudd is part-supported by the NIHR Cambridge Biomedical Research Centre, the British Heart Foundation and the Wellcome Trust. Dr. Newby is supported by the British Heart Foundation (CH/09/002). The Wellcome Trust Clinical Research Facility and the Clinical Research Imaging Centre are supported by National Health Service Research Scotland through National Health Service Lothian.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.subjectabdominal aortic aneurysmsen
dc.subjectmagnetic resonance imagingen
dc.subjectpositron emission tomographyen
dc.subjectcomputed tomographyen
dc.titlePositron Emission Tomography and Magnetic Resonance Imaging of Cellular Inflammation in Patients with Abdominal Aortic Aneurysmsen
dc.description.versionThis is the final version of the article. It first appeared from Elsevier via
prism.publicationNameEuropean Journal of Vascular and Endovascular Surgeryen
dc.rioxxterms.funderWellcome Trust
dc.contributor.orcidRudd, James [0000-0003-2243-3117]
rioxxterms.typeJournal Article/Reviewen

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Attribution-NonCommercial-NoDerivatives 4.0 International
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