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dc.contributor.authorAinsworth, Nicola Len
dc.contributor.authorMcLean, Maryen
dc.contributor.authorMcIntyre, Dominicken
dc.contributor.authorHoness, Davina Jen
dc.contributor.authorBrown, Anna Men
dc.contributor.authorHarden, Susan Ven
dc.contributor.authorGriffiths, Johnen
dc.date.accessioned2016-04-21T12:42:41Z
dc.date.available2016-04-21T12:42:41Z
dc.date.issued2016-04-18en
dc.identifier.citationAinsworth et al. Magnetic Resonance in Medicine (2016)en
dc.identifier.issn0740-3194
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/255113
dc.description.abstractPurpose: The sensitivity of the magnetization transfer ratio (MTR) and apparent diffusion coefficient (ADC) for early detection of brain metastases was investigated in mice and humans. Methods: Mice underwent MRI twice weekly for up to 31 days following intra-cardiac injection of the brain-homing breast cancer cell line MDA-MB231-BR. Patients with small cell lung cancer underwent quarterly MRI for a year. MTR and ADC were measured in regions of metastasis and matched contralateral tissue at the final time-point and in registered regions at earlier time-points. Texture analysis and linear discriminant analysis were performed to detect metastasis-containing slices. Results: Compared with contralateral tissue, mouse metastases had significantly lower MTR and higher ADC at the final time-point. Some lesions were visible at earlier time-points on the MTR and ADC maps: 24% of these were not visible on corresponding T2-weighted images. Texture analysis using the MTR maps showed 100% specificity and 98% sensitivity for metastasis at the final time-point, with 77% sensitivity 2-4 days earlier and 46% 5-8 days earlier. Only 2/16 patients developed metastases, and their penultimate scans were normal. Conclusion: Some brain metastases may be detected earlier on MTR than conventional T2; however, the small gain is unlikely to justify ‘predictive’ MRI.
dc.description.sponsorshipThe authors gratefully acknowledge the Cambridge Institute Biological Resources Unit for expert animal care and technical assistance, the Histopathology Core Facility, Drs Joe Frank and Diane Palmieri for providing the cell line, the advice of Dr. Dan Tozer, and the support of Cancer Research UK [grant number C14303/A17197], the Brian Cross Memorial Trust, the Addenbrooke’s Charitable Trust, the University of Cambridge, Hutchison Whampoa Ltd, the Cambridge Experimental Cancer Medicine Centre, and the NIHR Cambridge Biomedical Research Centre.
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectMRIen
dc.subjectcanceren
dc.subjectmagnetization transferen
dc.subjectdiffusionen
dc.subjectbrain metastasisen
dc.subjecttexture analysisen
dc.titleQuantitative and textural analysis of magnetization transfer and diffusion images in the early detection of brain metastasesen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Wiley via https://doi.org/10.1002/mrm.26257en
prism.endingPage1995
prism.publicationDate2016en
prism.publicationNameMagnetic Resonance in Medicineen
prism.startingPage1987
prism.volume77en
dc.rioxxterms.funderCRUK
dc.rioxxterms.funderNIHR
dc.rioxxterms.projectidC14303/A17197
dcterms.dateAccepted2016-04-01en
rioxxterms.versionofrecord10.1002/mrm.26257en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-04-18en
dc.contributor.orcidMcLean, Mary [0000-0002-3752-0179]
dc.contributor.orcidMcIntyre, Dominick [0000-0002-0269-6545]
dc.contributor.orcidGriffiths, John [0000-0001-7369-6836]
dc.identifier.eissn1522-2594
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (C14303_do not transfer)
pubs.funder-project-idCancer Research UK (CB4110)
pubs.funder-project-id?Brian Cross Memorial Trust (GF3079)
cam.orpheus.successThu Jan 30 12:54:45 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Except where otherwise noted, this item's licence is described as Attribution 4.0 International