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Local Persistence of Novel MRSA Lineage after Hospital Ward Outbreak, Cambridge, UK, 2011–2013


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Authors

Toleman, Michelle S 
Reuter, Sandra 
Coll, Francesc 
Harrison, Ewan M 
Peacock, Sharon J 

Abstract

To the Editor: Previously, we reported the use of whole-genome sequencing to investigate a putative methicillin-resistant Staphylococcus aureus (MRSA) outbreak in 2011 in the special care baby unit (SCBU) at the Cambridge University Hospitals National Health Service Foundation Trust (CUH) in the United Kingdom (1). The report identified 26 related cases of infection with or asymptomatic carriage of MRSA and showed that transmission occurred within the SCBU, between mothers on a postnatal ward, and in the community; the outbreak apparently resolved at the end of 2011. The outbreak strain, sequence type (ST) 2371, was of a novel multilocus ST related to the dominant hospital-associated lineage in the UK (ST22, EMRSA-15), but unlike most ST22 strains, this strain was Panton-Valentine leucocidin–positive (2). Since then, ST2371 has been identified as a prevalent communityassociated MRSA clone in Southern India, and sporadic isolates have also been detected by whole-genome sequencing of MRSA in Denmark (3–5)

Description

Keywords

Bacteria, Cambridge, MRSA, Staphylococcus aureus, United Kingdom, infection control, nosocomial, staphylococci, Cross Infection, Disease Outbreaks, Genome, Bacterial, History, 21st Century, Humans, Methicillin-Resistant Staphylococcus aureus, Phylogeny, Polymorphism, Single Nucleotide, Staphylococcal Infections, United Kingdom

Journal Title

Emerging Infectious Diseases

Conference Name

Journal ISSN

1080-6040
1080-6059

Volume Title

22

Publisher

Centers for Disease Control and Prevention
Sponsorship
Medical Research Council (G1000803)
Medical Research Council (G1000803/1)
The study was supported by grants from the UKCRC Translational Infection Research (TIR) Initiative, and the Medical Research Council (Grant Number G1000803) with contributions to the Grant from the Biotechnology and Biological Sciences Research Council, the National Institute for Health Research on behalf of the Department of Health, and the Chief Scientist Office of the Scottish Government Health Directorate (to Prof. Peacock); by a Healthcare Infection Society Major Research Grant; and by Wellcome Trust grant number 098051 awarded to the Wellcome Trust Sanger Institute.