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dc.contributor.authorUsher-Smith, Julieten
dc.contributor.authorSharp, Stephenen
dc.contributor.authorGriffin, Simonen
dc.date.accessioned2016-05-10T10:56:18Z
dc.date.available2016-05-10T10:56:18Z
dc.date.issued2016-06-22en
dc.identifier.issn0959-8146
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/255949
dc.description.abstractThe spectrum effect describes the variation between settings in performance of tests used to predict, screen for, and diagnose disease. In particular, the predictive use of a test may be different when it is applied in a general population rather than in the study sample in which it was first developed. This article discusses the impact of the spectrum effect on measures of test performance, and its implications for the development, evaluation, application, and implementation of such tests.
dc.description.sponsorshipJUS is supported by a National Institute of Health Research (NIHR) Clinical Lectureship. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. SJS is supported by the Medical Research Council www.mrc.ac.uk [Unit Programme number MC_UU_12015/1].
dc.languageEnglishen
dc.language.isoenen
dc.publisherBMJ Group
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleThe spectrum effect in tests for risk prediction, screening, and diagnosisen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from the BMJ Group via https://doi.org/10.1136/bmj.i3139en
prism.numberi3139en
prism.publicationDate2016en
prism.publicationNameBritish Medical Journalen
prism.volume353en
dc.rioxxterms.funderNIHR
dc.rioxxterms.funderMRC
dc.rioxxterms.projectidMC_UU_12015/1
dcterms.dateAccepted2016-04-28en
rioxxterms.versionofrecord10.1136/bmj.i3139en
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-06-22en
dc.contributor.orcidUsher-Smith, Juliet [0000-0002-8501-2531]
dc.contributor.orcidSharp, Stephen [0000-0003-2375-1440]
dc.contributor.orcidGriffin, Simon [0000-0002-2157-4797]
dc.identifier.eissn1756-1833
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/4)
pubs.funder-project-idMRC (MC_UU_12015/1)
pubs.funder-project-idMedical Research Council (MC_U106179474)
cam.orpheus.successThu Jan 30 12:54:19 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International