Association between Childhood Psychiatric Disorders and Psychotic Experiences in Adolescence: a population-based longitudinal study
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Siebald, C., Khandaker, G., Zammit, S., Lewis, G., & Jones, P. (2016). Association between Childhood Psychiatric Disorders and Psychotic Experiences in Adolescence: a population-based longitudinal study. Comprehensive Psychiatry https://doi.org/10.1016/j.comppsych.2016.05.004
Background Adolescent psychotic experiences (PEs) are common, and are associated with both psychotic and non-psychotic illnesses. In order to examine psychopathological and cognitive antecedents of adolescent PEs, we have conducted a longitudinal study of common childhood psychiatric disorders and subsequent adolescent PEs in the population-based prospective ALSPAC birth cohort. Method Depression, anxiety, attention deficit hyperactivity disorder, oppositional defiant or conduct disorder, and pervasive developmental disorder were diagnosed according to DSM-IV criteria in 8253 participants at age 8 years. IQ was assessed by WISC-III also at 8 years. PEs, depressive and anxiety symptoms were assessed at 13 years. Logistic regression calculated odds ratio (OR) for PEs at 13 years associated with psychiatric disorders at 8 years. Linear regression calculated mean difference in IQ between groups with and without psychiatric disorder. Mediating effects of IQ, mood and anxiety symptoms on the psychiatric disorder-PEs relationship were examined. Results In total, 599 children were assessed to have a DSM-IV psychiatric disorder at 8 years (7.2%). These children compared with those without any psychiatric disorder performed worse on all measures of IQ; adjusted mean difference in total IQ − 6.17 (95% CI, − 7.86, − 4.48). Childhood psychiatric disorders were associated with PEs subsequently in adolescence; adjusted OR 1.96 (95% CI, 1.47–2.68). The association between psychiatric disorder and subsequent PEs was partly mediated by, independently, IQ deficit at 8 years and depressive and anxiety symptoms at 13 years. Conclusions The findings indicate adolescent PEs are associated with general cognitive ability and past and present psychopathological factors.
Prof Jones acknowledges support from the Wellcome Trust (095844/Z/11/Z & 088869/Z/09/Z) and NIHR (RP-PG-0606-1335). The UK Medical Research Council and the Wellcome Trust grant ref. 092731 and the University of Bristol provide core support for the ALSPAC cohort.
CAMBS & PETERBOROUGH NHS FOUND TRUST (FB NHS/NIHR) (RP-PG-0606-1335)
Academy of Medical Sciences (unknown)
Wellcome Trust (088869/Z/09/Z)
Wellcome Trust (095844/Z/11/Z)
Wellcome Trust (093875/Z/10/Z)
External DOI: https://doi.org/10.1016/j.comppsych.2016.05.004
This record's URL: https://www.repository.cam.ac.uk/handle/1810/256037
Attribution-NonCommercial-NoDerivs 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by-nc-nd/2.0/uk/
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