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dc.contributor.authorBerck, Matthew Een
dc.contributor.authorKhandelwal, Avinashen
dc.contributor.authorClaus, Lindseyen
dc.contributor.authorHernandez-Nunez, Luisen
dc.contributor.authorSi, Guangweien
dc.contributor.authorTabone, Christopher Jen
dc.contributor.authorLi, Fengen
dc.contributor.authorTruman, James Wen
dc.contributor.authorFetter, Rick Den
dc.contributor.authorLouis, Matthieuen
dc.contributor.authorSamuel, Aravinthan DTen
dc.contributor.authorCardona, Alberten
dc.date.accessioned2016-06-13T14:39:42Z
dc.date.available2016-06-13T14:39:42Z
dc.date.issued2016-05-13en
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/256286
dc.description.abstractThe sense of smell enables animals to react to long-distance cues according to learned and innate valences. Here, we have mapped with electron microscopy the complete wiring diagram of the Drosophila larval antennal lobe, an olfactory neuropil similar to the vertebrate olfactory bulb. We found a canonical circuit with uniglomerular projection neurons (uPNs) relaying gain-controlled ORN activity to the mushroom body and the lateral horn. A second, parallel circuit with multiglomerular projection neurons (mPNs) and hierarchically connected local neurons (LNs) selectively integrates multiple ORN signals already at the first synapse. LN-LN synaptic connections putatively implement a bistable gain control mechanism that either computes odor saliency through panglomerular inhibition, or allows some glomeruli to respond to faint aversive odors in the presence of strong appetitive odors. This complete wiring diagram will support experimental and theoretical studies towards bridging the gap between circuits and behavior.
dc.languageEnglishen
dc.language.isoenen
dc.publishereLife
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleThe wiring diagram of a glomerular olfactory systemen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from eLife via http://dx.doi.org/10.7554/eLife.14859.en
prism.publicationDate2016en
prism.publicationNameeLifeen
dc.identifier.doi10.17863/CAM.227
dcterms.dateAccepted2016-05-06en
rioxxterms.versionofrecord10.7554/eLife.14859en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-05-13en
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Reviewen


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International