Show simple item record

dc.contributor.authorSurendran, Praveenen
dc.contributor.authorDrenos, Fotiosen
dc.contributor.authorYoung, Robinen
dc.contributor.authorWarren, Helenen
dc.contributor.authorCook, James Pen
dc.contributor.authorManning, Alisa Ken
dc.contributor.authorGrarup, Nielsen
dc.contributor.authorSim, Xuelingen
dc.contributor.authorBarnes, Danielen
dc.contributor.authorWitkowska, Kateen
dc.contributor.authorStaley, Jamesen
dc.contributor.authorTragante, Viniciusen
dc.contributor.authorTukiainen, Taruen
dc.contributor.authorYaghootkar, Haniehen
dc.contributor.authorMasca, Nicholasen
dc.contributor.authorFreitag, Daniel Fen
dc.contributor.authorFerreira, Teresaen
dc.contributor.authorGiannakopoulou, Olgaen
dc.contributor.authorTinker, Andrewen
dc.contributor.authorHarakalova, Magdalenaen
dc.contributor.authorMihailov, Evelinen
dc.contributor.authorLiu, Chunyuen
dc.contributor.authorKraja, Aldi Ten
dc.contributor.authorNielsen, Sune Fallgaarden
dc.contributor.authorRasheed, Asifen
dc.contributor.authorSamuel, Mariaen
dc.contributor.authorZhao, Weien
dc.contributor.authorBonnycastle, Lori Len
dc.contributor.authorJackson, Anne Uen
dc.contributor.authorNarisu, Narisuen
dc.contributor.authorSwift, Amy Jen
dc.contributor.authorSoutham, Lorraineen
dc.contributor.authorMarten, Jonathanen
dc.contributor.authorHuyghe, Jeroen Ren
dc.contributor.authorStančáková, Alenaen
dc.contributor.authorFava, Cristianoen
dc.contributor.authorOhlsson, Thereseen
dc.contributor.authorMatchan, Angelaen
dc.contributor.authorStirrups, Kathleenen
dc.contributor.authorJette, Bork-Jensenen
dc.contributor.authorGjesing, Anette Pen
dc.contributor.authorKontto, Jukkaen
dc.contributor.authorPerola, Markusen
dc.contributor.authorSusan, Shaw-Hawkinsen
dc.contributor.authorHavulinna, Aki Sen
dc.contributor.authorZhang, Heen
dc.contributor.authorDonnelly, Louise Aen
dc.contributor.authorGroves, Christopher Jen
dc.contributor.authorRayner, N Williamen
dc.contributor.authorNeville, Matt Jen
dc.contributor.authorRobertson, Neil Ren
dc.contributor.authorYiorkas, Andrianos Men
dc.contributor.authorHerzig, Karl-Heinzen
dc.contributor.authorKajantie, Eeroen
dc.contributor.authorZhang, Weihuaen
dc.contributor.authorWillems, Saraen
dc.contributor.authorLannfelt, Larsen
dc.contributor.authorMalerba, Giovannien
dc.contributor.authorSoranzo, Nicoleen
dc.contributor.authorTrabetti, Elisabettaen
dc.contributor.authorVerweij, Nieken
dc.contributor.authorEvangelou, Evangelosen
dc.contributor.authorMoayyeri, Alirezaen
dc.contributor.authorVergnaud, Anne-Claireen
dc.contributor.authorNelson, Christopher Pen
dc.contributor.authorPoveda, Alaitzen
dc.contributor.authorVarga, Tibor Ven
dc.contributor.authorCaslake, Murielen
dc.contributor.authorde, Craen Anton JMen
dc.contributor.authorTrompet, Stellaen
dc.contributor.authorLuan, Jian'anen
dc.contributor.authorScott, Robert Aen
dc.contributor.authorHarris, Sarah Een
dc.contributor.authorLiewald, David CMen
dc.contributor.authorMarioni, Riccardoen
dc.contributor.authorMenni, Cristinaen
dc.contributor.authorFarmaki, Aliki-Elenien
dc.contributor.authorHallmans, Göranen
dc.contributor.authorRenström, Fridaen
dc.contributor.authorHuffman, Jennifer Een
dc.contributor.authorHassinen, Maijaen
dc.contributor.authorBurgess, Stephenen
dc.contributor.authorVasan, Ramachandran Sen
dc.contributor.authorFelix, Janine Fen
dc.contributor.authorCHARGE-Heart, Failure Consortiumen
dc.contributor.authorUria-Nickelsen, Mariaen
dc.contributor.authorMalarstig, Andersen
dc.contributor.authorReily, Dermot Fen
dc.contributor.authorHoek, Maartenen
dc.contributor.authorVogt, Thomasen
dc.contributor.authorLin, Honghuangen
dc.contributor.authorLieb, Wolfgangen
dc.contributor.authorEchoGen, Consortiumen
dc.contributor.authorTraylor, Matthewen
dc.contributor.authorMarkus, Hughen
dc.contributor.authorMETASTROKE, Consortiumen
dc.contributor.authorHighland, Heather Men
dc.contributor.authorJustice, Anne Een
dc.contributor.authorMarouli, Eirinien
dc.contributor.authorGIANT, Consortiumen
dc.contributor.authorLindström, Jaanaen
dc.contributor.authorUusitupa, Mattien
dc.contributor.authorKomulainen, Pirjoen
dc.contributor.authorLakka, Timo Aen
dc.contributor.authorRauramaa, Raineren
dc.contributor.authorPolasek, Ozrenen
dc.contributor.authorRudan, Igoren
dc.contributor.authorRolandsson, Oloven
dc.contributor.authorFranks, Paul Wen
dc.contributor.authorDedoussis, Georgeen
dc.contributor.authorSpector, Timothy Den
dc.contributor.authorEPIC-InterAct, Consortiumen
dc.contributor.authorJousilahti, Pekkaen
dc.contributor.authorMännistö, Satuen
dc.contributor.authorDeary, Ian Jen
dc.contributor.authorStarr, John Men
dc.contributor.authorLangenberg, Claudiaen
dc.contributor.authorWareham, Nicholasen
dc.contributor.authorBrown, Morris Jen
dc.contributor.authorDominiczak, Anna Fen
dc.contributor.authorConnell, John Men
dc.contributor.authorJukema, J Wouteren
dc.contributor.authorSattar, Naveeden
dc.contributor.authorFord, Ianen
dc.contributor.authorPackard, Chris Jen
dc.contributor.authorEsko, Tõnuen
dc.contributor.authorMägi, Reediken
dc.contributor.authorMetspalu, Andresen
dc.contributor.authorde, Boer Rudolf Aen
dc.contributor.authorvan, der Meer Peteren
dc.contributor.authorvan, der Harst Pimen
dc.contributor.authorLifelines, Cohort Studyen
dc.contributor.authorGambaro, Giovannien
dc.contributor.authorIngelsson, Eriken
dc.contributor.authorLind, Larsen
dc.contributor.authorde, Bakker Paul IWen
dc.contributor.authorNumans, Mattijs Een
dc.contributor.authorBrandslund, Ivanen
dc.contributor.authorChristensen, Crameren
dc.contributor.authorPetersen, Eva RBen
dc.contributor.authorKorpi-Hyövälti, Eevaen
dc.contributor.authorOksa, Heikkien
dc.contributor.authorChambers, John Cen
dc.contributor.authorKooner, Jaspal Sen
dc.contributor.authorBlakemore, Alexandra IFen
dc.contributor.authorFranks, Steveen
dc.contributor.authorJarvelin, Marjo-Riittaen
dc.contributor.authorHusemoen, Lise Len
dc.contributor.authorLinneberg, Allanen
dc.contributor.authorSkaaby, Teaen
dc.contributor.authorThuesen, Betinaen
dc.contributor.authorKarpe, Fredriken
dc.contributor.authorTuomilehto, Jaakkoen
dc.contributor.authorDoney, Alex SFen
dc.contributor.authorMorris, Andrew Den
dc.contributor.authorPalmer, Colin NAen
dc.contributor.authorHolmen, Oddgeir Lingaasen
dc.contributor.authorHveem, Kristianen
dc.contributor.authorWiller, Cristen Jen
dc.contributor.authorTuomi, Tiinamaijaen
dc.contributor.authorGroop, Leifen
dc.contributor.authorKäräjämäki, AnneMarien
dc.contributor.authorPalotie, Aarnoen
dc.contributor.authorRipatti, Samulien
dc.contributor.authorSalomaa, Veikkoen
dc.contributor.authorAlam, Dewan Sen
dc.contributor.authorMajumder, Abdulla al Shafien
dc.contributor.authorDi, Angelantonio Emanueleen
dc.contributor.authorChowdhury, Rajiven
dc.contributor.authorMcCarthy, Mark Ien
dc.contributor.authorPoulter, Neilen
dc.contributor.authorStanton, Alice Ven
dc.contributor.authorSever, Peteren
dc.contributor.authorAmouyel, Philippeen
dc.contributor.authorArveiler, Dominiqueen
dc.contributor.authorBlankenberg, Stefanen
dc.contributor.authorFerrières, Jeanen
dc.contributor.authorKee, Franken
dc.contributor.authorKuulasmaa, Karien
dc.contributor.authorMüller-Nurasyid, Martinaen
dc.contributor.authorVeronesi, Giovannien
dc.contributor.authorVirtamo, Jarmoen
dc.contributor.authorDeloukas, Panosen
dc.contributor.authorWellcome, Trust Case Control Consortiumen
dc.contributor.authorElliott, Paulen
dc.contributor.authorUnderstanding, Society Scientific Groupen
dc.contributor.authorZeggini, Eleftheriaen
dc.contributor.authorKathiresan, Sekaren
dc.contributor.authorMelander, Olleen
dc.contributor.authorKuusisto, Johannaen
dc.contributor.authorLaakso, Markkuen
dc.contributor.authorPadmanabhan, Sandoshen
dc.contributor.authorPorteous, Daviden
dc.contributor.authorHayward, Carolineen
dc.contributor.authorScotland, Generationen
dc.contributor.authorCollins, Francis Sen
dc.contributor.authorMohlke, Karen Len
dc.contributor.authorHansen, Torbenen
dc.contributor.authorPedersen, Olufen
dc.contributor.authorBoehnke, Michaelen
dc.contributor.authorStringham, Heather Men
dc.contributor.authorEPIC-CVD, Consortiumen
dc.contributor.authorFrossard, Philippeen
dc.contributor.authorChristopher, Newton-Chehen
dc.contributor.authorCHARGE+, Exome Chip Blood Pressure Consortiumen
dc.contributor.authorTobin, Martin Den
dc.contributor.authorNordestgaard, Børge Grønneen
dc.contributor.authorTD-GENES, Consortiumen
dc.contributor.authorGoTDGenes, Consortiumen
dc.contributor.authorExomeBP, Consortiumen
dc.contributor.authorCHD, Exome Consortiumen
dc.contributor.authorCaulfield, Mark Jen
dc.contributor.authorMahajan, Anubhaen
dc.contributor.authorMorris, Andrew Pen
dc.contributor.authorTomaszewski, Maciejen
dc.contributor.authorSamani, Nilesh Jen
dc.contributor.authorSaleheen, Danishen
dc.contributor.authorAsselbergs, Folkert Wen
dc.contributor.authorLindgren, Cecilia Men
dc.contributor.authorDanesh, Johnen
dc.contributor.authorWain, Louise Ven
dc.contributor.authorButterworth, Adamen
dc.contributor.authorHowson, Joannaen
dc.contributor.authorMunroe, Patricia Ben
dc.date.accessioned2016-06-15T13:59:14Z
dc.date.available2016-06-15T13:59:14Z
dc.date.issued2016-09-12en
dc.identifier.issn1061-4036
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/256330
dc.description.abstractHigh blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to ~192,000 individuals, and used ~155,063 samples for independent replication. We identified 31 novel blood pressure or hypertension associated genetic regions in the general population, including three rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5mmHg/allele) than common variants. Multiple rare, nonsense and missense variant associations were found in A2ML1 and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.
dc.description.sponsorshipWellcome Trust (068545/Z/02)
dc.languageEnglishen
dc.language.isoenen
dc.publisherNature Publishing Group
dc.titleTrans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertensionen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/ng.3654en
prism.endingPage1161
prism.publicationDate2016en
prism.publicationNameNature Geneticsen
prism.startingPage1151
prism.volume48en
dc.identifier.doi10.17863/CAM.272
dcterms.dateAccepted2016-08-02en
rioxxterms.versionofrecord10.1038/ng.3654en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-09-12en
dc.contributor.orcidSurendran, Praveen [0000-0002-4911-6077]
dc.contributor.orcidBarnes, Daniel [0000-0002-3781-7570]
dc.contributor.orcidMarten, Jonathan [0000-0001-6916-2014]
dc.contributor.orcidStirrups, Kathleen [0000-0002-6823-3252]
dc.contributor.orcidSoranzo, Nicole [0000-0003-1095-3852]
dc.contributor.orcidLuan, Jian'an [0000-0003-3137-6337]
dc.contributor.orcidBurgess, Stephen [0000-0001-5365-8760]
dc.contributor.orcidTraylor, Matthew [0000-0001-6624-8621]
dc.contributor.orcidMarkus, Hugh [0000-0002-9794-5996]
dc.contributor.orcidLangenberg, Claudia [0000-0002-5017-7344]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidChowdhury, Rajiv [0000-0003-4881-5690]
dc.contributor.orcidDanesh, John [0000-0003-1158-6791]
dc.contributor.orcidButterworth, Adam [0000-0002-6915-9015]
dc.contributor.orcidHowson, Joanna [0000-0001-7618-0050]
dc.identifier.eissn1546-1718
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/1)
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idMRC (MR/L003120/1)
pubs.funder-project-idWellcome Trust (204623/Z/16/Z)
pubs.funder-project-idMRC (G0800270)
pubs.funder-project-idWellcome Trust (100114/Z/12/Z)
pubs.funder-project-idMedical Research Council (MC_U106179471)
pubs.funder-project-idWellcome Trust (091310/Z/10/Z)
pubs.funder-project-idBritish Heart Foundation (RG/08/014/24067)
pubs.funder-project-idBritish Heart Foundation (RG/13/13/30194)
rioxxterms.freetoread.startdate2017-03-12


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record