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dc.contributor.authorMcIntyre, Rebecca Een
dc.contributor.authorNicod, Jérômeen
dc.contributor.authorRobles-Espinoza, Carla Danielaen
dc.contributor.authorMaciejowski, Johnen
dc.contributor.authorCai, Naen
dc.contributor.authorHill, Jenniferen
dc.contributor.authorVerstraten, Ruthen
dc.contributor.authorIyer, Viveken
dc.contributor.authorRust, Alistair Gen
dc.contributor.authorBalmus, Gabrielen
dc.contributor.authorMott, Richarden
dc.contributor.authorFlint, Jonathanen
dc.contributor.authorAdams, David Jen
dc.date.accessioned2016-06-29T10:46:21Z
dc.date.available2016-06-29T10:46:21Z
dc.date.issued2016-05-27en
dc.identifier.issn2160-1836
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/256526
dc.description.abstractIn mammals the regulation of genomic instability plays a key role in tumor suppression and also controls genome plasticity, which is important for recombination during the processes of immunity and meiosis. Most studies to identify regulators of genomic instability have been performed in cells in culture or in systems that report on gross rearrangements of the genome, yet subtle differences in the level of genomic instability can contribute to whole organism phenotypes such as tumour predisposition. Here we performed a genome-wide association study in a population of 1379 outbred Crl:CFW(SW)-US_P08 mice to dissect the genetic landscape of micronucleus formation, a biomarker of chromosomal breaks, whole chromosome loss, and extra-nuclear DNA. Variation in micronucleus levels is a complex trait with a genome-wide heritability of 53.1%. We identify seven loci influencing micronucleus formation (false discovery rate<5%), and define candidate genes at each locus. Intriguingly at several loci we find evidence for sex-specific genetic effects in micronucleus formation, with a locus on chromosome 11 being specific to males.
dc.description.sponsorshipThis work was supported by Cancer Research UK and the Wellcome Trust.
dc.languageEnglishen
dc.language.isoenen
dc.publisherGenetics Society of America
dc.rightsAttribution 4.0 International*
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectGWASen
dc.subjectgenomic stabilityen
dc.subjectoutbreden
dc.subjectQTLen
dc.subjectmicronucleien
dc.titleA Genome-Wide Association Study for Regulators of Micronucleus Formation in Miceen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from the Genetics Society of America via http://dx.doi.org/10.1534/g3.116.030767en
prism.publicationDate2016en
prism.publicationNameG3: Genes, Genomes, Geneticsen
dc.identifier.doi10.17863/CAM.472
datacite.cites.urlhttp://mus.well.ox.ac.uk/gscandb/en
datacite.cites.urlhttp://outbredmice.orgen
dcterms.dateAccepted2016-05-24en
rioxxterms.versionofrecord10.1534/g3.116.030767en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-05-27en
dc.contributor.orcidBalmus, Gabriel [0000-0003-2872-4468]
dc.identifier.eissn2160-1836
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successThu Jan 30 12:57:57 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International