Selective inhibition mediates the sequential recruitment of motor pools
Authors
Zwart, Maarten F
Pulver, Stefan R
Truman, James W
Fushiki, Akira
Cardona, Albert
Publication Date
2016-07-14Journal Title
Neuron
ISSN
0896-6273
Publisher
Elsevier (Cell Press)
Volume
91
Pages
615-628
Language
English
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Zwart, M. F., Pulver, S. R., Truman, J. W., Fushiki, A., Cardona, A., & Landgraf, M. (2016). Selective inhibition mediates the sequential recruitment of motor pools. Neuron, 91 615-628. https://doi.org/10.1016/j.neuron.2016.06.031
Abstract
Locomotor systems generate diverse motor patterns to produce the movements underlying behavior, requiring that motor neurons be recruited at various phases of the locomotor cycle. Reciprocal inhibition produces alternating motor patterns; however, the mechanisms that generate other phasic relationships between intrasegmental motor pools are unknown. Here, we investigate one such motor pattern in the Drosophila larva, using a multidisciplinary approach including electrophysiology and ssTEM-based circuit reconstruction. We find that two motor pools that are sequentially recruited during locomotion have identical excitable properties. In contrast, they receive input from divergent premotor circuits. We find that this motor pattern is not orchestrated by differential excitatory input but by a GABAergic interneuron acting as a delay line to the later-recruited motor pool. Our findings show how a motor pattern is generated as a function of the modular organization of locomotor networks through segregation of inhibition, a potentially general mechanism for sequential motor patterns.
Sponsorship
This work was supported by the Howard Hughes Medical Institute, the HHMI Janelia Visitor Program (MFZ and ML), an Isaac Newton Trust/ISSF Wellcome Trust and a Wellcome Trust grant (092986/Z) to ML.
Funder references
Wellcome Trust (092986/Z/10/Z)
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1016/j.neuron.2016.06.031
This record's URL: https://www.repository.cam.ac.uk/handle/1810/256609
Rights
Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International
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