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dc.contributor.authorBlake, Ginaen
dc.contributor.authorWatson, Ericaen
dc.date.accessioned2016-07-06T13:35:31Z
dc.date.available2016-07-06T13:35:31Z
dc.date.issued2016-06-18en
dc.identifier.issn1367-5931
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/256643
dc.description.abstractThere are numerous benefits to elucidating how our environment affects our health: from a greater understanding of adaptation to disease prevention. Evidence shows that stressors we are exposed to during our lifetime might cause disease in our descendants. Transgenerational epigenetic inheritance involves the transmission of ‘information’ over multiple generations via the gametes independent of the DNA base sequence. Despite extensive research, the epigenetic mechanisms remain unclear. Analysis of model organisms exposed to environmental insults (e.g., diet manipulation, stress, toxin exposure) or carrying mutations in the epigenetic regulatory machinery indicates that inheritance of altered DNA methylation, histone modifications, or non-coding RNAs are key mechanisms. Tracking inherited epigenetic information and its effects for multiple generations is a significant challenge to overcome.
dc.description.sponsorshipG.E.T.B. is supported by a studentship from the Wellcome Trust 4-year PhD programme in Developmental Mechanisms. E.D.W. is a Lister Research Prize fellow and was supported by an Isaac Newton Trust/Wellcome Trust ISSF/University of Cambridge joint research grant.
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.titleUnravelling the complex mechanisms of transgenerational epigenetic inheritanceen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.cbpa.2016.06.008en
prism.endingPage107
prism.publicationDate2016en
prism.publicationNameCurrent Opinion in Chemical Biologyen
prism.startingPage101
prism.volume33en
dc.identifier.doi10.17863/CAM.579
dcterms.dateAccepted2016-06-08en
rioxxterms.versionofrecord10.1016/j.cbpa.2016.06.008en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2016-06-18en
dc.contributor.orcidBlake, Gina [0000-0002-6485-799X]
dc.contributor.orcidWatson, Erica [0000-0003-4496-2271]
dc.identifier.eissn1879-0402
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idLister Institute of Preventive Medicine ()
rioxxterms.freetoread.startdate2017-06-18


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