Research data supporting "Combination of enabling technologies to improve and describe the stereoselectivity of Wolff-Staudinger cascade reaction"
Śliwiński, Éric P.
Kabeshov, Mikhail A.
Ley, Steven V.
University of Cambridge
MetadataShow full item record
Musio, B., Mariani, F., Śliwiński, É. P., Kabeshov, M. A., Odajima, H., & Ley, S. V. (2016). Research data supporting "Combination of enabling technologies to improve and describe the stereoselectivity of Wolff-Staudinger cascade reaction" [Dataset]. https://doi.org/10.17863/CAM.654
A new single-mode bench-top resonator was evaluated for the microwave-assisted flow generation of primary ketenes by thermal decomposition of alpha-diazoketones at high temperature. A number of amides and beta-lactams were obtained by in situ ketene generation and reaction with amines and imines respectively in good to excellent yields. The preferential formation of trans-configured beta-lactams was observed during the [2+2] Staudinger cycloaddition of a range of ketenes with different imines under controlled reaction conditions. Some insights into the mechanism of this reaction at high temperature are reported and a new web-based molecular viewer, which takes advantage from augmented reality (AR) technology, is also described for a faster interpretation of computed data.
Adobe Acrobat, Mozilla Firefox, Google Chrome
microwave, Wolff, Staudinger, flow, Augmented Reality, molecular visualization
Related software/sourcecode: https://github.com/es605/HTMoLAR
EPSRC [EP/K009494/1, EP/K039520/1 and EP/M004120/1]
Embargo Lift Date
This record's DOI: https://doi.org/10.17863/CAM.654
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
Recommended or similar items
The following licence files are associated with this item: