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dc.contributor.authorTorres, Alice Aen
dc.contributor.authorAlbarnaz, Jonas Den
dc.contributor.authorBonjardim, Cláudio Aen
dc.contributor.authorSmith, Geoffreyen
dc.date.accessioned2016-07-15T13:38:08Z
dc.date.available2016-07-15T13:38:08Z
dc.date.issued2016-06-16en
dc.identifier.issn0022-1317
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/256755
dc.description.abstractVaccinia virus (VACV) is a poxvirus and encodes many proteins that modify the host cell metabolism or inhibit the host response to infection. For instance, it is known that VACV infection can activate the MAPK/AP-1 pathway and inhibit activation of the pro-inflammatory transcription factor NF-κB. Since NF-κB and MAPK/AP-1 share common upstream activators we investigated whether six different VACV Bcl-2-like NF-κB inhibitors can also influence MAPK/AP-1 activation. Data presented show that proteins A52, B14 and K7 each contribute to AP-1 activation during VACV infection and when expressed individually outwith infection. B14 induced the greatest stimulation of AP-1 and further investigation showed B14 activated mainly the MAPKs ERK and JNK, and their substrate c-Jun (a component of AP-1). These data indicate that the same viral protein can have different effects on distinct signalling pathways, in blocking NF-κB activation whilst leading to MAPK/AP-1 activation.
dc.description.sponsorshipThis work was funded by grants from the Medical Research Council, the Wellcome Trust, the Minas Gerais State’s Foundation for Research Support (FAPEMIG) and the National Council for Scientific and Technological Development (CNPq - Brazil).
dc.languageEnglishen
dc.language.isoenen
dc.publisherMicrobiology Society
dc.titleMultiple Bcl-2 family immunomodulators from vaccinia virus regulate MAPK/AP-1 activationen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from the Microbiology Society via http://dx.doi.org/10.1099/jgv.0.000525en
prism.publicationDate2016en
prism.publicationNameJournal of General Virologyen
dc.identifier.doi10.17863/CAM.690
dcterms.dateAccepted2016-06-16en
rioxxterms.versionofrecord10.1099/jgv.0.000525en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-06-16en
dc.contributor.orcidSmith, Geoffrey [0000-0002-3730-9955]
dc.identifier.eissn1465-2099
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (090315/B/09/Z)
pubs.funder-project-idWELLCOME TRUST (090315/B/09/A)
rioxxterms.freetoread.startdate2017-06-16


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