Research data supporting “CARD9 negatively regulates NLRP3-induced IL-1b production upon Salmonella infection of macrophages”
Wright, John A.
Monie, Tom P.
Bryant, Clare E.
University of Cambridge
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Pereira, M. C. A., Tourlomousis, P., Wright, J. A., Monie, T. P., & Bryant, C. E. (2016). Research data supporting “CARD9 negatively regulates NLRP3-induced IL-1b production upon Salmonella infection of macrophages” [Dataset]. https://doi.org/10.17863/CAM.778
Interleukin 1β (IL-1β) is a pro-inflammatory cytokine required for host control of bacterial infections, and its production must be tightly regulated to prevent excessive inflammation. Here we identify show a surprising negative regulatory role for caspase recruitment domain-containing protein 9 (CARD9), a protein associated with induction of pro-inflammatory cytokines by fungi, has a negative role on IL-1β production during bacterial infection. CARD9 negatively regulates IL-1β productionSpecifically, in response to activation of the nucleotide oligomerization domain receptor pyrin-domain containing protein 3 (NLRP3) by Salmonella infection, CARD9 negatively regulates IL-1β by fine-tuning pro-IL-1β expression, reducing SYK-mediated NLRP3 activation and repressing inflammasome inflammasome-associated caspase-8 activity. CARD9 is suppressed during Salmonella enterica serovar Typhimurium infection, facilitating increased IL-1β production. CARD9 is, therefore, a central signalling hub that co-ordinates a pathogen- specific host inflammatory response.
Salmonella, CARD9, IL-1β, immunity, infection, inflammasome
Publication Reference: https://doi.org/10.1038/ncomms12874
BBSRC [BB/K006436/1], Wellcome Trust [Investigator 108045/Z/15/Z], CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil)
This record's DOI: https://doi.org/10.17863/CAM.778
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
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