Organoids from adult liver and pancreas: stem cell biology and biomedical utility
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Publication Date
2016-06-27Journal Title
Developmental Biology
ISSN
0012-1606
Publisher
Elsevier
Language
English
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Hindley, C. J., Cordero-Espinoza, L., & Huch Ortega, M. (2016). Organoids from adult liver and pancreas: stem cell biology and biomedical utility. Developmental Biology https://doi.org/10.1016/j.ydbio.2016.06.039
Abstract
The liver and pancreas are critical organs maintaining whole body metabolism. Historically, the expansion of adult-derived cells from these organs in vitro has proven challenging and this in turn has hampered studies of liver and pancreas stem cell biology, as well as being a roadblock to disease modelling and cell replacement therapies for pathologies in these organs. Recently, defined culture conditions have been described which allow the in vitro culture and manipulation of adult-derived liver and pancreatic material. Here we review these systems and assess their physiological relevance, as well as their potential utility in biomedicine.
Keywords
organoid, 3D cultures, pancreas, liver, niche signals, stem cell
Sponsorship
CH is supported by the Herchel Smith Fund. LCE is jointly funded by a Wellcome Trust Four-Year PhD Studentship with the Stem Cell Biology and Medicine Programme and by a Wellcome Cambridge Trust Scholarship. MH is a Wellcome Trust Sir Henry Dale Fellow and is jointly funded by the Wellcome Trust and the Royal Society (104151/Z/14/Z).
Funder references
WELLCOME TRUST (104151/Z/14/Z)
MRC (MC_PC_12009)
Identifiers
External DOI: https://doi.org/10.1016/j.ydbio.2016.06.039
This record's URL: https://www.repository.cam.ac.uk/handle/1810/256926
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International, Attribution-NonCommercial-NoDerivatives 4.0 International
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