AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials
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Wheeler, G. M., Sweeting, M. J., & Mander, A. P. (2016). AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials. PLOS One, 11 (e0159026)https://doi.org/10.1371/journal.pone.0159026
In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI), requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download for each design that contains tabulated operating characteristics and informative plots, which can then be compared with other dose-escalation methods. We present a step-by-step guide on how to use this application and provide several illustrative examples of its capabilities.
GMW and APM are supported by the UK Medical Research Council (www.mrc.ac.uk; grant number G0800860). MJS is supported by a European Research Council Advanced Investigator Award: EPIC-Heart (https://erc.europa.eu; grant number 268834), the UK Medical Research Council (grant number MR/L003120/1), the British Heart Foundation (www.bhf.org.uk), and the Cambridge National Institute for Health Research Biomedical Research Centre (http://www.cambridge-brc.org.uk). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
External DOI: https://doi.org/10.1371/journal.pone.0159026
This record's URL: https://www.repository.cam.ac.uk/handle/1810/256941
Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International
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