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dc.contributor.authorLeng, Yen
dc.contributor.authorCappuccio, FPen
dc.contributor.authorSurtees, PGen
dc.contributor.authorLuben, Roberten
dc.contributor.authorBrayne, Carolen
dc.contributor.authorKhaw, Kay-Teeen
dc.date.accessioned2016-08-09T14:57:31Z
dc.date.available2016-08-09T14:57:31Z
dc.date.issued2016-06-28en
dc.identifier.issn0939-4753
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/257014
dc.description.abstractBackground and aims Few studies have prospectively examined the relationship between daytime napping and risk of type 2 diabetes. We aimed to study the effects of daytime napping and the joint effects of napping and sleep duration in predicting type 2 diabetes risk in a middle- to older-aged British population. Methods and results In 1998–2000, 13 465 individuals with no known diabetes participating in the European Prospective Investigation into Cancer-Norfolk study reported daytime napping habit and 24-h sleep duration. Incident type 2 diabetes cases were identified through multiple data sources until 31 July 2006. After adjustment for age and sex, daytime napping was associated with a 58% higher diabetes risk. Further adjustment for education, marital status, smoking, alcohol intake, physical activity, comorbidities and hypnotic drug use had little influence on the association, but additional adjustment for BMI and Waist Circumference attenuated the Odds ratio (OR) (95% CI) to 1.30 (1.01, 1.69). The adjusted ORs (95% CI) associated with short and long sleep duration were 1.46 (1.10, 1.90) and 1.64 (1.16, 2.32), respectively. When sleep duration and daytime napping were examined together, the risk of developing diabetes more than doubled for those who took day naps and had less than 6 h of sleep, compared to those who did not nap and had 6–8 h of sleep. Conclusion Daytime napping was associated with an increased risk of type 2 diabetes, particularly when combined with short sleep duration. Further physiological studies are needed to confirm the interaction between different domains of sleep in relation to diabetes risk.
dc.description.sponsorshipThe design and conduct of the EPIC-Norfolk study and collection and management of the data was supported by programme grants from the Medical Research Council UK (G9502233, G0300128) and Cancer Research UK (C865/A2883). Funding sources did not have a role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution 4.0 International*
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectsleepen
dc.subjecttype 2 diabetesen
dc.subjectepidemiologyen
dc.subjectprospectiveen
dc.subjectcohorten
dc.titleDaytime napping, sleep duration and increased 8-year risk of type 2 diabetes in a British populationen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Elsevier at http://dx.doi.org/10.1016/j.numecd.2016.06.006.en
prism.endingPage1003
prism.publicationDate2016en
prism.publicationNameNutrition, Metabolism and Cardiovascular Diseasesen
prism.startingPage996
prism.volume26en
dc.identifier.doi10.17863/CAM.942
dcterms.dateAccepted2016-06-17en
rioxxterms.versionofrecord10.1016/j.numecd.2016.06.006en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-06-28en
dc.contributor.orcidLuben, Robert [0000-0002-5088-6343]
dc.contributor.orcidBrayne, Carol [0000-0001-5307-663X]
dc.contributor.orcidKhaw, Kay-Tee [0000-0002-8802-2903]
dc.identifier.eissn1590-3729
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (unknown)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/N003284/1)
pubs.funder-project-idMRC (G1000143)
pubs.funder-project-idMRC (G0401527)
pubs.funder-project-idCancer Research UK (A2883)
datacite.issupplementedby.doi10.1016/j.numecd.2016.06.006en


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Except where otherwise noted, this item's licence is described as Attribution 4.0 International