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dc.contributor.authorTito, Nicholasen
dc.contributor.authorFrenkel, Daanen
dc.date.accessioned2016-08-10T07:46:58Z
dc.date.available2016-08-10T07:46:58Z
dc.date.issued2016-07-18en
dc.identifier.issn1951-6355
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/257021
dc.description.abstractMultivalent particles competing for binding on the same surface can exhibit switch-like behaviour, depending on the concentration of receptors on the surface. When the receptor concentration is low, energy dominates the free energy of binding, and particles having a small number of strongly-binding ligands preferentially bind to the surface. At higher receptor concentrations, multivalent effects become significant, and entropy dominates the binding free energy; particles having many weakly-binding ligands preferentially bind to the surface. Between these two regimes there is a “switch-point”, at which the surface binds the two species of particles equally strongly. We demonstrate that a simple theory can account for this switch-like behaviour and present numerical calculations that support the theoretical predictions. We argue that binding selectivity based on receptor density, rather than identity, may have practical applications.
dc.description.sponsorshipEuropean Union Seventh Framework Programme (FP/2007-2013) European Research Council (Grant Agreement n. 607602 (“SASSYPOL”)), Engineering and Physical Sciences Research Council (Grant ID: EP/I001352/1)
dc.languageEnglishen
dc.language.isoenen
dc.publisherSpringer
dc.rightsAttribution 4.0 International*
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleSwitch-like surface binding of competing multivalent particlesen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Springer via http://dx.doi.org/10.1140/epjst/e2016-60119-6en
prism.publicationDate2016en
prism.publicationNameThe European Physical Journal Special Topicsen
dc.identifier.doi10.17863/CAM.949
dcterms.dateAccepted2016-06-21en
rioxxterms.versionofrecord10.1140/epjst/e2016-60119-6en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-07-18en
dc.contributor.orcidFrenkel, Daan [0000-0002-6362-2021]
dc.identifier.eissn1951-6401
rioxxterms.typeJournal Article/Reviewen
datacite.issupplementedby.doi10.17863/CAM.582en
cam.orpheus.successThu Jan 30 10:20:23 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International