A multicomponent approach for the preparation of homoallylic alcohols
Royal Society of Chemistry
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Poh, J. S., Lau, S. H., Dykes, I. G., Tran, D. N., Battilocchio, C., & Ley, S. (2016). A multicomponent approach for the preparation of homoallylic alcohols. Chemical Science https://doi.org/10.1039/C6SC02581A
Here we report the in situ generation of transient allylic boronic species, by reacting TMSCHN2 and E-vinyl boronic acids, followed by their subsequent trapping with aldehydes as electrophiles to yield homoallylic alcohols. This metal-free reaction was initially discovered by the use of a flow chemistry approach to generate a variety of homoallylic alcohols in a straightforward fashion and then transferred to a batch protocol.
Is supplemented by: https://doi.org/10.17863/CAM.591
We are grateful to the Cambridge Home and European Scholarship Scheme (J. S. P.), Croucher Foundation (S. H. L.), the Swiss National Science Foundation (D. N. T.), Pfizer Worldwide Research & Development (C. B.), and the Engineering and Physical Sciences Research Council (S. V. L. grant no. EP/K0099494/1 and EP/K039520/1) for financial support.
External DOI: https://doi.org/10.1039/C6SC02581A
This record's URL: https://www.repository.cam.ac.uk/handle/1810/257275
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