Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition
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Authors
Bandelow, Borwin
Baldwin, David
Abelli, Marianna
Bolea-Alamanac, Blanca
Bourin, Michel
Cinosi, Eduardo
Davies, Simon
Domschke, Katharina
Fineberg, Naomi
Grünblatt, Edna
Jarema, Marek
Kim, Yong-Ku
Maron, Eduard
Masdrakis, Vasileios
Mikova, Olya
Nutt, David
Pallanti, Stefano
Pini, Stefano
Ströhle, Andreas
Thibaut, Florence
Won, Eunsoo
Wedekind, Dirk
Wichniak, Adam
Woolley, Jade
Zwanzger, Peter
Riederer, Peter
Publication Date
2016-07-15Journal Title
The World Journal of Biological Psychiatry
ISSN
1562-2975
Publisher
Taylor & Francis
Language
English
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Bandelow, B., Baldwin, D., Abelli, M., Bolea-Alamanac, B., Bourin, M., Chamberlain, S., Cinosi, E., et al. (2016). Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition. The World Journal of Biological Psychiatry https://doi.org/10.1080/15622975.2016.1190867
Abstract
${\bf Objective:}$ Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD).
${\bf Methods:}$ Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network.
${\bf Results:}$ The present article (Part II) summarises findings on potential biomarkers in neurochemistry (neurotransmitters such as serotonin, norepinephrine, dopamine or GABA, neuropeptides such as cholecystokinin, neurokinins, atrial natriuretic peptide, or oxytocin, the HPA axis, neurotrophic factors such as NGF and BDNF, immunology and CO$_2$ hypersensitivity), neurophysiology (EEG, heart rate variability) and neurocognition. The accompanying paper (Part I) focuses on neuroimaging and genetics.
${\bf Conclusions:}$ Although at present, none of the putative biomarkers is sufficient and specific as a diagnostic tool, an abundance of high quality research has accumulated that should improve our understanding of the neurobiological causes of anxiety disorders, OCD and PTSD.
Keywords
anxiety disorders, neuroimaging, genetic, neurochemistry, neurobiology, review
Sponsorship
The present work was supported by the Anxiety Disorders Research Network (ADRN) within the European College of Neuropsychopharmacology Network Initiative (ECNP-NI). Katherina Domschke’s work was supported by the German Research Foundation (DFG), Collaborative Research Centre “Fear, Anxiety, Anxiety Disorders” SFB-TRR-58, project C02.
Funder references
WELLCOME TRUST (110049/Z/15/Z)
Identifiers
External DOI: https://doi.org/10.1080/15622975.2016.1190867
This record's URL: https://www.repository.cam.ac.uk/handle/1810/257277
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