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dc.contributor.authorBandelow, Borwinen
dc.contributor.authorBaldwin, Daviden
dc.contributor.authorAbelli, Mariannaen
dc.contributor.authorBolea-Alamanac, Blancaen
dc.contributor.authorBourin, Michelen
dc.contributor.authorChamberlain, Samuelen
dc.contributor.authorCinosi, Eduardoen
dc.contributor.authorDavies, Simonen
dc.contributor.authorDomschke, Katharinaen
dc.contributor.authorFineberg, Naomien
dc.contributor.authorGrünblatt, Ednaen
dc.contributor.authorJarema, Mareken
dc.contributor.authorKim, Yong-Kuen
dc.contributor.authorMaron, Eduarden
dc.contributor.authorMasdrakis, Vasileiosen
dc.contributor.authorMikova, Olyaen
dc.contributor.authorNutt, Daviden
dc.contributor.authorPallanti, Stefanoen
dc.contributor.authorPini, Stefanoen
dc.contributor.authorStröhle, Andreasen
dc.contributor.authorThibaut, Florenceen
dc.contributor.authorVaghi, Matildeen
dc.contributor.authorWon, Eunsooen
dc.contributor.authorWedekind, Dirken
dc.contributor.authorWichniak, Adamen
dc.contributor.authorWoolley, Jadeen
dc.contributor.authorZwanzger, Peteren
dc.contributor.authorRiederer, Peteren
dc.date.accessioned2016-08-15T15:51:35Z
dc.date.available2016-08-15T15:51:35Z
dc.date.issued2016-07-15en
dc.identifier.issn1562-2975
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/257277
dc.description.abstract${\bf Objective:}$ Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). ${\bf Methods:}$ Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network. ${\bf Results:}$ The present article (Part II) summarises findings on potential biomarkers in neurochemistry (neurotransmitters such as serotonin, norepinephrine, dopamine or GABA, neuropeptides such as cholecystokinin, neurokinins, atrial natriuretic peptide, or oxytocin, the HPA axis, neurotrophic factors such as NGF and BDNF, immunology and CO$_2$ hypersensitivity), neurophysiology (EEG, heart rate variability) and neurocognition. The accompanying paper (Part I) focuses on neuroimaging and genetics. ${\bf Conclusions:}$ Although at present, none of the putative biomarkers is sufficient and specific as a diagnostic tool, an abundance of high quality research has accumulated that should improve our understanding of the neurobiological causes of anxiety disorders, OCD and PTSD.
dc.description.sponsorshipThe present work was supported by the Anxiety Disorders Research Network (ADRN) within the European College of Neuropsychopharmacology Network Initiative (ECNP-NI). Katherina Domschke’s work was supported by the German Research Foundation (DFG), Collaborative Research Centre “Fear, Anxiety, Anxiety Disorders” SFB-TRR-58, project C02.
dc.languageEnglishen
dc.language.isoenen
dc.publisherTaylor & Francis
dc.subjectanxiety disordersen
dc.subjectneuroimagingen
dc.subjectgeneticen
dc.subjectneurochemistryen
dc.subjectneurobiologyen
dc.subjectreviewen
dc.titleBiological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognitionen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Taylor & Francis via http://dx.doi.org/10.1080/15622975.2016.1190867en
prism.publicationDate2016en
prism.publicationNameThe World Journal of Biological Psychiatryen
dc.identifier.doi10.17863/CAM.1207
dcterms.dateAccepted2016-07-01en
rioxxterms.versionofrecord10.1080/15622975.2016.1190867en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-07-15en
dc.contributor.orcidChamberlain, Samuel [0000-0001-7014-8121]
dc.contributor.orcidVaghi, Matilde [0000-0002-0999-9055]
dc.identifier.eissn1814-1412
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (110049/Z/15/Z)
rioxxterms.freetoread.startdate2017-07-15


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